基于数据挖掘技术探讨中药治疗急性附睾炎用药规律  

Discussion of Medication Rules of Chinese Medicine for Acute Epididymitis Based on Data Mining

作　　者：方跃坤 陈盛镱 谢作钢 杜宝昕 FANG Yuekun;CHEN Shengyi;XIE Zuogang;DU Baoxin(Wenzhou Hospital of Integrated Traditional Chinese and Western Medicine,Wenzhou Zhejiang 325700,China;Chongqing Traditional Chinese Medicine Hospital,Chongqing 400021,China)

机构地区：[1]温州市中西医结合医院,浙江温州325700 [2]重庆市中医院,重庆400021

出　　处：《新中医》2024年第20期1-7,共7页New Chinese Medicine

基　　金：重庆市科卫联合中医药科研项目(2019Y3203);重庆市科研机构绩效激励引导专项项目(cstc2019jxj1130026);浙江省名老中医专家传承工作室建设计划项目(GZS2020042);浙江省中医药科技计划项目(2024ZF144)。

摘　　要：目的:基于数据挖掘技术探讨中药治疗急性附睾炎的用药规律。方法:检索中国知网(CNKI)、万方数据知识服务平台(WF)自建库至2023年8月1日公开发表的中药治疗急性附睾炎的相关文献。分别建立内服、外用中药处方数据库,运用中医传承辅助平台V3.5软件统计药物使用频次、功效、四气、五味、归经,以及进行关联规则和聚类分析。结果:筛选后获取文献95篇,其中内服中药文献74篇,外用中药文献21篇。得到102首处方,包括63首内服中药处方和39首外用中药处方。内服中药使用频次排名前5的是甘草、当归、柴胡、泽泻、龙胆草,外用中药使用频次排名前5的是大黄、黄柏、天花粉、甘草、白芷。内服中药功效多见清热、活血化瘀、利水渗湿,外用中药功效多见清热、活血化瘀、泻下。内服、外用中药四气皆以寒性为主,其次为温性;五味皆以苦味为主,其次为甘味或辛味。内服中药排名前3的归经是肝、肺、心经,外用中药排名前3的归经是脾、肝、肺经。通过关联规则分析,内服中药获得30条常用药物组合、8条核心药物关联规则;外用中药获得6条常用药物组合、7条核心药物关联规则。通过聚类分析,内服中药获得4个核心药物组合,外用中药获得3个核心药物组合。结论:中药治疗急性附睾炎无论内服还是外用,都强调清热解毒、活血化瘀,组方皆以苦寒清热药为主。内服中药核心药物组合针对急性附睾炎早期湿热蕴结、热毒壅盛和后期瘀血阻络、瘀毒互结之病机,分别治以清热利湿、活血解毒和活血化瘀、清热解毒、软坚散结之法。外用中药核心药物组合则常以清热利湿药、清热解毒药配以活血化瘀药,以改善局部症状为主。Objective:To discuss the administration rules of Chinese medicine for acute epididymitis based on data mining.Methods:The related literatures on the treatment of acute epididymitis with Chinese medicine published by China National Knowledge Infrastructure(CNKI)and Wanfang Data Knowledge Service Platform(WF)from the establishment of database to August 1st,2023 were searched.The database of Chinese medicine prescriptions for oral administration and external application was established respectively,and the use frequency,curative effects,four qi,five flavors and channel entry of Chinese medicinals were counted by using Traditional Chinese Medicine Inheritance Assistant Platform(V3.5),and association rules and cluster analysis were carried out.Results:After screening,a total of 95 articles were obtained,including 74 on oral administration of Chinese medicine and 21 on external application with Chinese medicine.A total of 102 prescriptions,including 63 Chinese medicine prescriptions for oral administration and 39 for external application.The top five Chinese medicinals in frequency of oral administration were Glycyrrhizae Radix et Rhizoma,Angelicae Sinensis Radix,Bupleuri Radix,Alismatis Rhizoma and Chinese Gentian and in the frequency of external application were Rhei Radix et Rhizoma,Phellodendri Chinensis Cortex,Trichosanthis Radix,Glycyrrhizae Radix et Rhizoma and Angelicae Dahuricae Radix.The curative effects of Chinese medicinals for internal use are more common in clearing heat,activating blood and resolving stasis,and inducing diuresis to drain dampness,and those of Chinese medicinals for external application are more common in clearing heat,activating blood and resolving stasis,and purgation.The four qi of Chinese medicinals for oral administration and external application is mainly cold,followed by warm;their flavor is mainly bitter,followed by sweet or pungent.The top three channel entries of Chinese medicinals for oral administration are the liver,lung and heart,and those of Chinese medicinals for external

关 键 词：急性附睾炎 中药 内服 外用 清热解毒 活血化瘀 数据挖掘 用药规律 

分 类 号：R277.5[医药卫生—中医学]