二合汤辅助西医常规疗法治疗糖尿病周围神经病变临床研究  

Clinical Study on Erhe Decoction Assisting Conventional Treatment of Western Medicine for Diabetic Peripheral Neuropathy

作　　者：胡美娅 管子函 卢翔 HU Meiya;GUAN Zihan;LU Xiang(Department of Endocrinology,Wenzhou Traditional Chinese Medicine Hospital of Zhejiang Chinese Medical University,Wenzhou Zhejiang 325000,China)

机构地区：[1]浙江中医药大学附属温州中医院内分泌科,浙江温州325000

出　　处：《新中医》2024年第20期65-69,共5页New Chinese Medicine

基　　金：温州市科技计划项目(Y20210810)。

摘　　要：目的:观察二合汤辅助西医常规治疗糖尿病周围神经病变(DPN)的临床疗效。方法:按随机数字表法将88例痰瘀阻络证DPN患者分为治疗组与对照组各44例,期间治疗组剔除1例,对照组剔除2例。对照组给予降糖降脂、静脉注射甲钴胺注射液等西医常规治疗,治疗组在对照组基础上加用二合汤治疗。治疗3个月后评估2组临床疗效、中医证候评分、血糖[空腹血糖(FBG)、餐后2 h血糖(P2hBG)]、周围神经传导速度[感觉神经传导速度(SNCV)、运动神经传导速度(MNCV)]及血清炎症因子[C-反应蛋白(CRP)、白细胞介素-6 (IL-6)]水平。结果:治疗组总有效率为97.67%,对照组为80.95%,2组比较,差异有统计学意义(P<0.05)。治疗后,2组中医证候评分均较治疗前降低(P<0.05),且治疗组中医证候评分低于对照组(P<0.05)。治疗后,2组FBG、P2hBG水平均较治疗前降低(P<0.05),且治疗组2项指标均低于对照组(P<0.05)。治疗后,2组正中神经、腓总神经SNCV、MNCV均较治疗前升高(P<0.05),且治疗组上述各项指标水平均高于对照组(P<0.05)。治疗后,2组CRP、IL-6水平均较治疗前降低(P<0.05),且治疗组CRP、IL-6水平均低于对照组(P<0.05)。结论:二合汤辅助西医常规治疗痰瘀阻络证DPN疗效确切,可改善患者中医证候,减轻机体炎症反应,降低血糖水平,提高周围神经传导速度。Objective:To observe the clinical effect of Erhe Decoction assisting conventional treatment of western medicine on diabetic peripheral neuropathy(DPN).Methods:A total of 88 DPN patients with syndrome of phlegm-blood stasis obstructing the collaterals were divided into treatment group and control group according to the random number table method,with 44 cases in each group.During the treatment,one case was excluded from the treatment group and two cases from the control group.The control group was given conventional treatment of western medicine such as medicines for reducing blood glucose and lowering lipid,and intravenous injection of Mecobalamin Injection,and the treatment group was treated with Erhe Decoction based on the treatment of the control group.After three months of treatment,the clinical effects,traditional Chinese medicine(TCM)syndrome scores,levels of blood glucose[fasting blood glucose(FBG)and 2-hour postprandial blood glucose(P2hBG)],peripheral nerve conduction velocity[sensory nerve conduction velocity(SNCV)and motor nerve conduction velocity(MNCV)]and levels of serum inflammatory factors[C-reactive protein(CRP)and interleukin-6(IL-6)]in the two groups were evaluated.Results:The total effective rate was 97.67%in the treatment group and 80.95%in the control group,the difference being significant(P<0.05).After treatment,the TCM syndrome scores in the two groups were reduced when compared with those before treatment(P<0.05),and the above scores in the treatment group were lower than those in the control group(P<0.05).After treatment,the levels of FBG and P2hBG in the two groups were down-regulated when compared with those before treatment(P<0.05),and the above two levels in the treatment group were lower than those in the control group(P<0.05).After treatment,the SNCV and MNCV of median nerve and common peroneal nerve in the two groups were elevated when compared with those before treatment(P<0.05),and the above two indexes in the treatment group were higher than those in the control group(P<0.05).A

关 键 词：糖尿病周围神经病变 痰瘀阻络证 二合汤 周围神经传导速度 炎症因子 

分 类 号：R587.2[医药卫生—内分泌]