PI3K/AKT信号通路在良性前列腺增生中的作用及中医药干预研究进展  

Research progress on the role of PI3K/AKT signaling pathway in benign prostatic hyperplasia and traditional Chinese medicine intervention

作　　者：赵渊博 赵永强[2] 甘德成 卢刚刚 李生龙 ZHAO Yuanbo;ZHAO Yongqiang;GAN Decheng;LU Ganggang;LI Shenglong(School of Traditional Chinese and Western Medicine,Gansu University of Chinese Medicine,Lanzhou 730000,China;Department of Urology,Gansu Provincial Hospital of Traditional Chinese Medicine,Lanzhou 730050,China;Department of Classical Chinese Medicine,Gansu Provincial Hospital of Traditional Chinese Medicine,Lanzhou 730050,China)

机构地区：[1]甘肃中医药大学中西医结合学院,兰州730000 [2]甘肃省中医院泌尿外科,兰州730050 [3]甘肃省中医院中医经典医学科,兰州730050

出　　处：《数理医药学杂志》2024年第10期775-785,共11页Journal of Mathematical Medicine

摘　　要：良性前列腺增生(benign prostatic hyperplasia,BPH)是一种常见的男性泌尿系统疾病,其发病机制复杂。磷脂酰肌醇-3-激酶(phosphatidylinositide 3-kinases,PI3K)/蛋白激酶B(protein kinase B,AKT)信号通路的活化与前列腺细胞增殖、凋亡、迁移及炎症反应等密切相关,通过调节该信号通路,可以有效控制前列腺组织的异常增生。中医药作为一种重要的替代疗法,具有多成分、多通路、多靶点的优势,并具有调节机体内平衡的特点,临床上被广泛应用于BPH的治疗。近年来研究表明,中医药可通过抑制PI3K/AKT信号通路的表达和活化以及调节相关调控因子的表达以改善BPH。本综述通过综合分析和总结PI3K/AKT信号通路在BPH中的作用,并从BPH的病因病机、中医内治法、中医外治法等方面提供一种全面了解BPH病理机制和中医药干预治疗的途径,以期为BPH的防治提供新的策略。Benign prostatic hyperplasia(BPH)is a common male urinary system disease with a complex pathogenesis.The activation of phosphatidylinositide 3-kinases(PI3K)/protein kinase B(AKT)signaling pathway is closely related to the proliferation,apoptosis,migration of prostate cells and inflammatory response.By regulating this signaling pathway,abnormal hyperplasia of prostate tissue can be effectively controlled.Traditional Chinese medicine(TCM),as an important alternative therapy,has the advantages of multiple components,pathways,and targets,as well as the ability to regulate balance within the body.It is widely used in the treatment of BPH in clinical practice.Recent studies have shown that TCM can improve BPH by inhibiting the expression and activation of PI3K/AKT signaling pathway and regulating the expression of related regulatory factors.This review comprehensively analyzed and summarized the role of PI3K/AKT signaling pathway in BPH and its relationship with TCM,providing a pathway for comprehensively understanding the pathological mechanism of BPH and TCM intervention and treatment from the aspects of etiology and pathogenesis,TCM internal treatment,TCM external treatment,etw.It is expected to provide new strategies for the prevention and treatment of BPH.

关 键 词：良性前列腺增生 磷脂酰肌醇-3-激酶/蛋白激酶B信号通路 前列腺细胞 中医药 

分 类 号：R697.3[医药卫生—泌尿科学]