解毒泻肺合剂治疗老年重症肺炎(痰热壅肺证)临床观察  

Clinical Observation of the Efficacy of the Jiedu Xiefei Mixture in Treating Elderly Patients with Severe Pneumonia(Syndrome of Phlegm-heat Obstructing Lung)

作　　者：刘振航 谢婷 张凯[1] 李娜[2] 陈扬波[2] Liu Zhenhang;Xie Ting;Zhang Kai;Li Na;Chen Yangbo(Zhejiang Chinese Medical University,Zhejiang,Hangzhou 310053,China)

机构地区：[1]浙江中医药大学,浙江杭州310053 [2]浙江省立同德医院,浙江杭州311122

出　　处：《中国中医急症》2024年第10期1773-1776,共4页Journal of Emergency in Traditional Chinese Medicine

基　　金：浙江省基础公益研究计划项目(LGF22H150011)。

摘　　要：目的 观察解毒泻肺合剂治疗老年重症肺炎(痰热壅肺证)患者的疗效并探寻其作用机制。方法 将60例患者采用随机数字表法分为对照组与观察组各30例。对照组给予西医常规治疗,观察组在西医常规治疗的基础上予解毒泻肺合剂鼻饲,治疗周期14 d。比较两组治疗效果。结果 治疗后观察组中医整体有效率为80.00%,高于对照组的63.33%(P <0.05);观察组治疗后C反应蛋白(CRP)、白细胞计数(WBC)、白细胞介素-6(IL-6)下降更明显(P <0.05),急性生理与慢性健康评分(APACHEⅡ评分)、临床肺部感染评分(CPIS评分)改善更显著(P <0.05)。结论 解毒泻肺合剂可减轻炎症反应,改善临床症状,治疗老年重症肺炎(痰热壅肺证)患者疗效显著。Objective:To observe the efficacy of the Jiedu Xiefei mixture in treating elderly patients with severe pneumonia(syndrome of phlegm-heat obstructing lung)and to explore its mechanism of action.Methods:60 pa-tients were randomly divided into a control group and an observation group of 30 patients each using the random number table method.The control group received routine western medical treatment,while the observation group re-ceived Jiedu Xiefei mixture via nasogastric tube in addition to western medical treatment.The treatment duration was 14 days.The therapeutic effects of both groups were compared.Results:After treatment,the overall TCM ef-fective rate in the observation group was 80.00%,which was higher than 63.33%in the control group(P<0.05).Additionally,the observation group showed a more significant decrease in C-reactive protein(CRP),white blood cell count(WBC),and interleukin-6(IL-6)levels(P<0.05),and more remarkable improvements in the Acute Physiology and Chronic Health EvaluationⅡ(APACHEⅡ)score and Clinical Pulmonary Infection Score(CPIS)(P<0.05)compared with the control group.Conclusion:Jiedu Xiefei mixture can alleviate inflammatory reac-tions and improve clinical symptoms,demonstrating significant efficacy in treating elderly patients with severe pneumonia(syndrome of phlegm-heat obstructing lung).

关 键 词：老年重症肺炎 解毒泻肺合剂 痰热壅肺 临床观察 

分 类 号：R563.1[医药卫生—呼吸系统]