阿魏酸哌嗪联合达格列净治疗2型糖尿病肾病的临床疗效  

Clinical Efficacy of Ferulic Acid Piperazine Combined with Dapagliflozin in the Treatment of Type 2 Diabetic Nephropathy

作　　者：宋丹[1] 刘爽[1] 李继业[1] 葛龙菲 彭佳欣 杜少斐 SONG Dan;LIU Shuang;LI Jiye;GE Longfei;PENG Jiaxin;DU Shaofei(The First People’s Hospital of Zhengzhou,Henan Zhengzhou 450005)

机构地区：[1]郑州市第一人民医院,河南郑州450005

出　　处：《深圳中西医结合杂志》2024年第16期16-19,共4页Shenzhen Journal of Integrated Traditional Chinese and Western Medicine

基　　金：河南省医学科技攻关计划联合共建项目(LHGJ20210719)。

摘　　要：目的:回顾性分析阿魏酸哌嗪联合达格列净治疗2型糖尿病肾病(T2DN)的临床疗效。方法:选取在郑州市第一人民医院2022年1月至2023年11月治疗的86例T2DN患者病历资料,根据治疗方案将患者分为对照组(42例)与观察组(44例)。两组患者均予以常规治疗,同时予以达格列净治疗为对照组,予以达格列净联合阿魏酸哌嗪治疗为观察组。比较两组患者外周血血糖指标[空腹血糖(FBG)、糖化血红蛋白(HbA1c)、餐后2 h血糖(2h PG)]、肾功能[血肌酐(SCr)、24 h尿微量白蛋白、肾小球滤过率(eGFR)]、血清相关细胞因子[β2–微球蛋白(β2–MG)、脂蛋白相关磷脂酶A2(Lp–PLA2)、胱抑素C(Cys–C)、1,25–二羟维生素D_(3)(1,25–(OH)_(2)–D_(3))]及不良反应。结果:治疗4周、8周后两组患者外周血FBG、HbA1c、2h PG水平均较治疗前下降,差异具有统计学意义(P<0.05);治疗4周、8周后两组患者外周血FBG、HbA1c、2h PG水平比较,差异无统计学意义(P>0.05)。治疗4周、8周后两组患者SCr、24 h尿微量白蛋白水平均较治疗前下降,eGFR均较治疗前提高,且治疗4周、8周后观察组患者外周血SCr、24 h尿微量白蛋白水平均低于对照组,eGFR高于对照组,差异具有统计学意义(P<0.05)。治疗4周、8周后两组患者血清β2–MG、Lp–PLA2、Cys–C均较治疗前下降,且观察组患者较对照组更低,差异具有统计学意义(P<0.05);治疗8周后两组患者血清1,25–(OH)_(2)–D_(3)水平均较治疗前提高,差异具有统计学意义(P<0.05),但治疗8周后两组患者血清1,25–(OH)_(2)–D_(3)水平比较,差异无统计学意义(P>0.05)。两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论:阿魏酸哌嗪联合达格列净治疗T2DN可有效降低血糖,改善肾功能,且具有一定安全性。Objective To retrospectively investigate the clinical efficacy of ferulic acid piperazine combined with dapagliflozin in the treatment of type 2 diabetic nephropathy(T2DN).Methods Medical records of 86 T2DN patients treated in the First People’s Hospital of Zhengzhou from January 2022 to November 2023 were selected.Patients were divided into a control group(42 cases)and an observation group(44 cases)based on the treatment regimen.Both groups received conventional treatment and dapagliflozin,While the control group was treated with dapagliflozin,and the observation group was treated with dapagliflozin combined with ferulic acid piperazine.The blood glucose indicators[fasting blood glucose(FBG),glycosylated hemoglobin(HbA1c),2-hour postprandial blood glucose(2h PG)],renal function[serum creatinine(SCr),24-hour urinary microalbumin,estimated glomerular filtration rate(eGFR)],serum-related cytokines[β2-microglobulin(β2-MG),lipoprotein-associated phospholipase A2(Lp-PLA2),cystatin C(Cys-C),1,25-dihydroxyvitamin D_(3)(1,25-(OH)_(2)-D_(3))],and adverse reactions were compared between the two groups.Results After 4 and 8 weeks of treatment,the levels of FBG,HbA1c,and 2h PG in both groups decreased significantly compared to before treatment(P<0.05);however,no significant difference was found between the two groups(P>0.05).The levels of SCr and 24-hour urinary microalbumin decreased,while the levels of eGFR increased after 4 and 8 weeks of treatment in both groups,with the observation group showing lower levels of SCr and 24-hour urinary microalbumin and higher level of eGFR than the control group,indicating statistical significance(P<0.05).After 4 and 8 weeks of treatment,the level ofβ2-MG,Lp-PLA2,and Cys-C decreased in both groups,with the observation group showing lower levels than the control group,which were statistically significant(P<0.05).After 8 weeks of treatment,the levels of 1,25-(OH)_(2)-D_(3)increased in both groups compared to before treatment,showing statistical significance(P<0.05),but no significant

关 键 词：2型糖尿病 肾病 阿魏酸哌嗪 达格列净 

分 类 号：R587.2[医药卫生—内分泌]