孟鲁司特钠联合小儿定喘口服液治疗儿童咳嗽变异性哮喘的临床疗效  

Clinical Efficacy of Montelukast Sodium Combined with Pediatric Dingchuan Oral Liquid in the Treatment of Children with Cough Variant Asthma

作　　者：王玺 彭献华[1] 郑卫星 WANG Xi;PENG Xianhua;ZHENG Weixing(Sanmenxia Central Hospital,Henan Sanmenxia 472000)

机构地区：[1]三门峡市中心医院,河南三门峡472000

出　　处：《深圳中西医结合杂志》2024年第15期38-41,共4页Shenzhen Journal of Integrated Traditional Chinese and Western Medicine

摘　　要：目的:探究孟鲁司特钠联合小儿定喘口服液治疗儿童咳嗽变异性哮喘的临床疗效。方法:将三门峡市中心医院儿科2022年1月至2024年1月期间收治的咳嗽变异性哮喘儿童68例,以简单随机化法平均分为观察组与对照组,各34例。对照组患儿采用孟鲁司特钠治疗,观察组患儿在对照组的基础上联合小儿定喘口服液治疗,比较两组患儿的治疗效果、临床指标、免疫球蛋白水平。结果:观察组患儿治疗总有效率高于对照组,差异具有统计学意义(P<0.05);观察组患儿各临床指标时间均短于对照组,差异具有统计学意义(P<0.05);治疗后两组患儿血清免疫球蛋白A、免疫球蛋白G水平均升高,免疫球蛋白E水平均降低,且治疗后观察组患儿血清免疫球蛋白A、免疫球蛋白G水平高于对照组,免疫球蛋白E水平低于对照组,差异具有统计学意义(P<0.05)。结论:孟鲁司特钠联合小儿定喘口服液对于儿童咳嗽变异性哮喘具有良好的效果,有利于减轻患儿咳痰、咳嗽以及住院时长,并可改善患儿免疫球蛋白E、免疫球蛋白A和免疫球蛋白G的水平。Objective To explore the clinical efficacy of montelukast sodium combined with Pediatric Dingchuan Oral Liquid in the treatment of children with cough variant asthma.Methods A total of 68 children with cough variant asthma admitted to the Pediatrics Department of Sanmenxia Central Hospital from January 2022 to January 2024 were randomly divided into an observation group and a control group,with 34 cases in each group.The control group was treated with montelukast sodium,while the observation group was treated with Pediatric Dingchuan Oral Liquid in addition to the treatment in the control group.The treatment outcomes,clinical indicators,and immunoglobulin levels were compared between the two groups.Results The total effective rate of treatment in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).The clinical indicators’duration in the observation group was shorter than that in the control group,and the difference was statistically significant(P<0.05).After treatment,the serum levels of immunoglobulin A and immunoglobulin G increased,and the serum level of immunoglobulin E decreased in both groups.Moreover,the serum levels of immunoglobulin A and immunoglobulin G in the observation group were higher than those in the control group,and the serum level of immunoglobulin E was lower than that in the control group,with statistically significant differences(P<0.05).Conclusion Montelukast sodium combined with Pediatric Dingchuan Oral Liquid has a good effect on children with cough variant asthma,which is beneficial for reducing the duration of sputum,cough,and hospitalization,and can improve the serum levels of immunoglobulin E,immunoglobulin A,and immunoglobulin G in children.

关 键 词：咳嗽变异性哮喘 孟鲁司特钠 小儿定喘口服液 儿童 

分 类 号：R562.25[医药卫生—呼吸系统]