硬皮病中医证候和证候要素分布规律的临床文献分析  

Clinical Literature Analysis of TCM Syndromes and Distribution Patterns of Syndrome Elements in Scleroderma

作　　者：蔡国昌 安阳 杨佳霞 赵青青 文红 谢良山 CAI Guo-chang;AN Yang;YANG Jia-xia;ZHAO Qing-qing;WEN Hong;XIE Liang-shan

机构地区：[1]贵州中医药大学,贵州贵阳550025 [2]贵州中医药大学第二附属医院,贵州贵阳550002

出　　处：《风湿病与关节炎》2024年第10期5-8,32,共5页Rheumatism and Arthritis

基　　金：贵州省中医风湿免疫病临床研究中心项目(黔科合平台人才[2020]2202);贵州省高等学校中西医结合防治疾病转化医学重点实验室(黔教技[2023]017号);贵州中医药大学国家与省级科技创新人才团队培育项目(贵中医TD合字[2022]004号)。

摘　　要：目的:基于文献分析探讨硬皮病患者的中医证型及证素分布规律。方法:检索中国知网2008年12月至2023年12月有关硬皮病的中医临床研究文献,筛选文献后,通过Excel软件对文献数据进行统计分析。结果:共纳入10篇文献,涉及硬皮病患者887例,覆盖中国多个省份,中医证型主要是脾肾阳虚证(20.15%)、气滞血瘀肝肾失调证(11.92%)以及湿热阻络证(10.51%),涉及病例393个,约占总数的42.58%。在病位证素方面,肾、脾、肺的频次最高,总占比73.61%。而在病性证素中,瘀、湿和阳虚的提及频次位居前列,总占比62.92%。按病位证素的出现频率高低排序为肾、脾、肺、脉络、肝、心,而病性证素则以瘀、湿、阳虚、气滞、热、气虚居前6位。结论:目前中医对于硬皮病证型分类的标准尚未统一,而且不同地区之间的差异也相当明显。研究所揭示的证型和证素分布规律对硬皮病的中医证型标准化有一定促进作用,为临床实践提供指导。Objective:Based on literature analysis,this study aims to explore the TCM syndrome types and distribution patterns of syndrome elements in patients with scleroderma.Methods:Clinical research literature on scleroderma from December 2008 to December 2023 was retrieved from CNKI,screened and statistically analyzed using Excel software.Results:A total of 10 articles were included,involving 887 patients with scleroderma,covering several provinces in China.The main TCM syndrome types were spleen-kidney yang deficiency syndrome(20.15%),qi stagnation,blood stasis,liver-kidney imbalance syndrome(11.92%),and damp heat obstruction syndrome(10.51%),involving 393 cases,accounting for approximately 42.58%of the total.In terms of disease location and syndrome elements,the highest frequency was found in the kidney,spleen,and lung,accounting for 73.61%of the total.Among the pathological syndrome elements,the frequency of mentioning blood stasis,dampness,and yang deficiency ranked among the top,accounting for a total of 62.91%.According to the frequency of occurrence of pathological syndrome elements,kidney,spleen,lung,vessel and collateral,liver,and heart were ranked in high-low sequence,while topsix pathological syndrome elements werestasis,dampness,yang deficiency,qi stagn-ation,heat,and qi deficiency.Conclusion:Currently,there is no unified standard for the classification of scleroderma syndrome types in TCM,and the differences between regions are also quite obvious.The distribution pattern of syndrome types and syndrome elements revealed in the study has a certain promoting effect on the standardization of TCM syndrome types for scleroderma,providing guidance for clinical practice.

关 键 词：硬皮病 中医证候 中医证素 文献研究 

分 类 号：R259[医药卫生—中西医结合]