皮肤科门诊男性患者人乳头瘤病毒感染情况及分型  

Status and typing of human papillomavirus infection in male patients in dermatology outpatient department

作　　者：左安欣 钱影臣 张晓妹[1] 周丹 仝放 仇玮[1] ZUO An-xin;QIAN Ying-chen;ZHANG Xiao-mei;ZHOU Dan;TONG Fang;QIU Wei(Department of Pathology,Nanjing Jiangning Hospital,Nanjing 211100,China)

机构地区：[1]南京市江宁医院病理科,江苏南京211100

出　　处：《中国感染控制杂志》2024年第10期1258-1263,共6页Chinese Journal of Infection Control

基　　金：南京医科大学科技发展基金项目(NMUB20210148)。

摘　　要：目的分析皮肤科门诊男性患者人乳头瘤病毒(HPV)感染情况及基因亚型分布,为防治男性HPV感染提供参考。方法回顾性调查2022年1月-2023年3月在某院皮肤科门诊就诊并进行HPV检测的男性患者,并将全部受检患者分为5组:病毒性疣组、皮炎皮疹组、泌尿道感染组、包皮阴茎炎组、无症状组。统计分析患者年龄组成、临床诊断、症状类型与基因型分布之间的关系。结果共有1035例男性患者进行了HPV检测,567例检测阳性,阳性率54.78%。其中病毒性疣组286例,皮炎皮疹组164例,泌尿道感染组6例,包皮阴茎炎组109例,无症状组470例。21种HPV亚型均被检出,检出率位于前3位的亚型依次是6型(17.97%)、11型(12.37%)、52型(8.70%)。单一型HPV感染阳性率为29.86%,占54.50%。不同年龄组的感染阳性率、低危感染阳性率和多重混合型感染阳性率比较,差异均有统计学意义(均P<0.05)。<20岁年龄组感染阳性率高于20~<30岁组、30~<40岁组和40~<50岁组,差异均有统计学意义(均P<0.05)。阳性患者中199例(35.10%)无临床症状,368例(64.90%)有临床症状,主要表现为病毒性疣(40.74%,231例)。病毒性疣组中HPV阳性患者以低危型为主,占80.95%;包皮阴茎炎组中HPV阳性患者以高危型为主,占84.78%;无症状组中HPV阳性患者以高危型感染为主,占86.43%。结论皮肤科门诊男性HPV感染以单一型感染为主,低危型感染临床诊断主要表现为病毒性疣,高危型感染主要表现为包皮阴茎炎,无症状组中阳性感染者以高危型为主。Objective To analyze the status and gene subtype distribution of human papillomavirus(HPV)infection in male patients in dermatology outpatient department,provide reference for the prevention and treatment of male HPV infection.Methods Male patients who visited and conducted HPV detection in the dermatology outpatient department of a hospital from January 2022 to March 2023 were retrospectively surveyed.Patients were divi-ded into five groups:viral warts group,dermatitis and rash group,urinary tract infection group,balanoposthitis group,and asymptomatic group.Relationship between genotype distribution and patient age,clinical diagnosis,and symptom types was statistically analyzed.Results A total of 1035 male patients underwent HPV detection,out of which 567 were positive,with a positive detection rate of 54.78%.286,164,6,109,and 470 cases were from viral warts,dermatitis and rash,urinary tract infection,balanoposthitis,and asymptomatic group,respectively.21 subtypes of HPV were detected,with the top three subtypes being type 6(17.97%),11(12.37%),and 52(8.70%).The positive rate of single type HPV infection was 29.86%,accounting for 54.50%.Positive rates of infection,low-risk infection,and multiple mixed infection in different age groups were compared,differences were all statistically significant(all P<0.05).The positive infection rate in the age group of<20 years old was higher than that in the age groups of 20-<30,30-<40,and 40-<50 years old,differences were all statistically significant(all P<0.05).Among the positive patients,199 cases(35.10%)had no clinical symptoms,while 368(64.90%)had clinical symptoms,mainly manifested as viral warts(40.74%,n=231).In viral warts group,HPV-positive patients were mainly of low-risk type,accounting for 80.95%;In balanoposthitis group,HPV-positive patients were mainly of high-risk type,accounting for 84.78%;In asymptomatic group,HPV-positive patients were mainly infected with high-risk types,accounting for 86.43%.Conclusion HPV infection in male outpatient department of dermatol

关 键 词：人乳头瘤病毒 男性 基因型 临床症状 HPV 

分 类 号：R752[医药卫生—皮肤病学与性病学]