SARS-CoV-2 S蛋白与宿主细胞相互作用的相关受体研究进展  

Research advances in receptors related to interaction between SARS-CoV-2 S protein and host cells

作　　者：方晓敏 刘兴健 张锐钢 FANG Xiao-min;LIU Xing-jian;ZHANG Rui-gang(Department of Physiology,School of Basic Medical Sciences,Guangdong Medical University,Zhanjiang 524000,China)

机构地区：[1]广东医科大学基础医学院生理学教研室,广东湛江524000

出　　处：《中国感染控制杂志》2024年第10期1326-1332,共7页Chinese Journal of Infection Control

基　　金：国家自然科学基金项目(82000008)。

摘　　要：自2019年底新型冠状病毒(SARS-CoV-2)感染暴发以来,对其的研究成为热点。冠状病毒感染趋向性主要取决于刺突蛋白(spike protein,S蛋白)与细胞表面受体结合的能力,而S蛋白及其受体结合域(S-RBD)不仅在病毒与宿主细胞结合及病毒进入细胞中起着关键作用,还可以与宿主细胞表面受体如血管紧张素转化酶2(ACE2)、Toll样受体(TLRs)、分化集群(CD)147、神经纤毛蛋白-1(NRP-1)等结合并激活不同的信号通路,从而促进病毒入侵宿主细胞及引发炎症等一系列致病进程。因此,研究S蛋白与宿主细胞相互作用的相关受体具有重要意义。本文综述S蛋白与宿主细胞相互作用的相关受体,以期为新型冠状病毒感染的防治提供理论依据。Since the outbreak of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection at the end of 2019,its global research has become a hot spot.The tendency of coronavirus infection mainly depends on the ability of spike protein(S protein)binding to receptors on the cell surface.S protein and its receptor binding domain(S-RBD)not only play a key role in the binding of virus to host cells and the entry of virus into cells,they can also bind to host cell surface receptors such as angiotensin-converting enzyme 2(ACE2),Toll-like receptor(TLRs),cluster of differentiation(CD)147,and neuropilin 1(NRP-1),activating different signaling pathways,thus promoting virus to invade host cells and trigger a series of pathogenic processes such as inflammation.Therefore,it is of great significance to study receptors involving in the interaction between S protein and host cells.This article reviews the receptors related to the interaction between S protein and host cells,so as to provide theoretical basis for the prevention and treatment of SARS-CoV-2 infection.

关 键 词：新冠病毒 S蛋白 受体 相互作用 SARS-CoV-2 

分 类 号：R181.32[医药卫生—流行病学] R511[医药卫生—公共卫生与预防医学]