Is deep brain imaging on the brink of transformation with a bioluminescence molecule?  

作　　者：Shumao Xu Farid Manshaii Jun Chen 

机构地区：[1]Department of Bioengineering,University of California,Los Angeles,Los Angeles,USA

出　　处：《BMEMat(BioMedical Engineering Materials)》2024年第3期4-8,共5页生物医学工程材料（英文）

摘　　要：Cephalofurimazine(CFz),when paired with Antares luciferase,shows superior blood-brain barrier permeability and enhanced imaging depth and clarity for deep brain imaging.This bioluminescence provides a less invasive method for real-time monitoring of deep brain activity,with the potential to advance targeted therapies and deepen our understanding of brain functions.Further molecular engineering and localized delivery can reduce the potential toxicity of CFz and enhance its efficacy for clinical deep brain imaging.

关 键 词：bioluminescence molecule blood-brain barrier brain imaging 

分 类 号：R318[医药卫生—生物医学工程]