Carbon-based nanodots for biomedical applications and clinical transformation prospects  

作　　者：Haizhen Ding Tenghui Xiao Fangfang Ren Yu Qiu Zhiyang Shen Xuecheng Chen Ewa Mijowska Hongmin Chen 

机构地区：[1]State Key Laboratory of Vaccines for Infectious Diseases,Center for Molecular Imaging and Translational Medicine,Xiang an Biomedicine Laboratory,School of Public Health,Xiamen University,Xiamen,China [2]State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics,National Innovation Platform for Industry-Education Integration in Vaccine Research,Xiamen University,Xiamen,China [3]Faculty of Chemical Technology and Engineering,West Pomeranian University of Technology,Szczecin,Poland

出　　处：《BMEMat(BioMedical Engineering Materials)》2024年第3期9-27,共19页生物医学工程材料（英文）

基　　金：National Natural Science Foundation of China,Grant/Award Numbers:81771977,82172007;Scientific Research Foundation of Xiang An Biomedicine Laboratory,Grant/Award Number:2023XAKJ0101023;Science Fund for Distinguished Young Scholars of Fujian Province,Grant/Award Number:2021J06007。

摘　　要：Carbon dots(CDs),emerging as a promising class of nanomaterials,have garnered significant interest in the field of biomedicine due to their unique physicochemical properties.This review provides a comprehensive overview of the recent advancements in the biomedical applications of CDs,emphasizing their potential for revolutionizing diagnostics,therapy,and bio-imaging.We discuss the synthesis and functionalization of CDs,which are pivotal in tailoring their properties for specific biomedical applications.The applications of CDs in bioimaging include fluorescence imaging,magnetic resonance imaging,photoacoustic imaging,etc.Additionally,this review delves into the benefits of CDs in the treatment of diseases including cancer,inflammation and Alzheimer's,etc.Finally,we look forward to the future of CDs in the field of biomedicine,emphasizing the necessity of interdisciplinary collaboration to overcome current obstacles and facilitate the clinical translation of CDs-based technologies.This review aims to provide a summary and perspectives on the latest developments of CDs in biomedicine,hoping to inspire further research in this rapidly advancing field.

关 键 词：BIOIMAGING biomedical applications carbon dots structural design THERAPY 

分 类 号：R318[医药卫生—生物医学工程] TB383[医药卫生—基础医学]