Tumor Imaging by a^(99m)TcO_(4)^(−)-Labeled Cationic Polymeric Network  

作　　者：Jie Li Rongzhen Xie Baoyu Li Lixi Chen Wenhao Shen Yuting Zhao Qi Guo Long Chen Boqi Xu Xijian Chen Jingwen Guan Lei Chen Kai Yang Zhifang Chai Shuao Wang 

机构地区：[1]State Key Laboratory of Radiation Medicine and Protection,School for Radiological and Interdisciplinary Sciences(RAD-X)and Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions,Soochow University,Suzhou 215123 [2]Department of General Surgery,The First Affiliated Hospital of Soochow University,Suzhou 215000

出　　处：《CCS Chemistry》2024年第8期1868-1875,共8页中国化学会会刊（英文）

基　　金：supported by the Intergovernmental International Cooperation of the National Key R&D Program of China(grant no.2022YFE0105300);the National Natural Science Foundation of China(grant nos.21825601,22306136,21790374,22176139,and 22206144);the China National Postdoctoral Program for Innovative Talents(grant no.BX2021206);the China Postdoctoral Science Foundation(grant no.2021M702390);the Natural Science Foundation of Jiangsu(grant no.BK20230510);the National Key R&D Program of China(grant no.2018YFB1900203);the New Cornerstone Science Foundation through the XPLORER PRIZE.

摘　　要：Technetium-99m(^(99m)Tc)is the most used(>80%)radionuclide in the clinical nuclear diagnostic imaging procedure.The traditional approach to preparing ^(99m)Tc-based imaging agents utilizes stannous chloride(SnCl_(2))for the reduction of noncomplexing pertechnetate(^(99m)TcO_(4)^(−))to low-valent Tc[e.g.,Tc(IV)].This process,however,is difficult to control precisely and usually results in toxic SnCl_(2) residue and remaining 99mTc(VII),both of which are destructive to humans.Herein,we report a new strategy for preparing^(99m)TcO_(4)^(−)-labeled agents without adding any reductants.The deliberately designed nanoscale cationic polymeric network(SCU-CPN-3)shows excellent affinity for^(99m)TcO_(4)^(−)even at trace levels originating from the strong p-πinteraction with^(99m)TcO_(4)^(−).Impressively,record-fast labeling kinetics are observed,where almost quantitative labeling efficacy(>96%)can be achieved within 1 min,giving rise to a short labeling time and simple operation using a clinical kit.Both single-photon emission computed tomography(SPECT)images and ex vivo biodistribution of different tumor model analyses verify the potential feasibility of this strategy for tumor imaging.

关 键 词：^(99m)TcO_(4)^(−)-based agent tumor imaging fast-labeling kinetics high labeling efficiency no reductant 

分 类 号：TQ317[化学工程—高聚物工业]