High-Intensity Focused Ultrasound-Induced Disulfide Mechanophore Activation in Polymeric Nanostructures for Molecule Release  

作　　者：Jilin Fan Kuan Zhang Mingjun Xuan Xiang Gao Rostislav Vinokur Robert Göstl Lifei Zheng Andreas Herrmann 

机构地区：[1]DWI—Leibniz Institute for Interactive Materials,52056 Aachen [2]Institute of Technical and Macromolecular Chemistry,RWTH Aachen University,52074 Aachen [3]Wenzhou Institute,University of Chinese Academy of Sciences,325001 Wenzhou

出　　处：《CCS Chemistry》2024年第8期1895-1907,共13页中国化学会会刊（英文）

基　　金：supported by the German Research Foundation(grant nos.331065168,191948804,and 503981124);the National Natural Science Foundation of China(grant no.22277018);the Zhejiang Provincial Natural Science Foundation for Distinguished Young Scholars(grant no.LR23B030001);Wenzhou Institute,University of the Chinese Academy of Sciences(grant no.WIUCASQD2020015);M.X.acknowledges the financial support of the Alexander von Humboldt Foundation(grant no.3.5-CHN-1210658-HFST-P).

摘　　要：Ultrasound(US)activation of mechanophores in polymers that initiates cascade chemical reactions is a promising strategy for on-demand molecule release.However,the typical US frequency used for mechanochemistry is around 20 kHz,producing inertial cavitation that exceeds the tolerance threshold of biological systems.Here,high-intensity focused US(HIFU)as a mechanical stimulus is introduced to drive the activation of disulfide mechanophores in hyperbranched star polymers(HBSPs)and microgels(MGLs).The mechanism of molecular release is attributed to the thiol-disulfide exchange reaction and subsequent intramolecular cyclization.We reveal that HBSPs and MGLs effectively transduce HIFU as mechanical input to chemical output,demonstrated by the quantification of the release of fluorescent umbelliferone(UMB).Moreover,an in vitro study of drug release is carried out using camptothecin as the model drug,which is covalently loaded in MGLs,demonstrating the potential of our system for controlled drug delivery to cancer cells.

关 键 词：mechanophores polymer mechanochemistry polymeric nanostructures ultrasound drug release sonopharmacology 

分 类 号：TB383[一般工业技术—材料科学与工程]