A Case of Two Full Sisters Share Identical Genotypes on the X Chromosome  

作　　者：Jinpei Zhang Guangbin Zhao Shicheng Hao Chong Chen Yan Shi Xinyue Xiao Le Wang Li Yuan 

机构地区：[1]Collaborative Innovation Center of Judicial Civilization,Beijing,China [2]Key Laboratory of Evidence Science(China University of Political Science and Law),Ministry of Education,Beijing,China [3]Key Laboratory of Forensic Genetics of Ministry of Public Security,Institute of Forensic Science,Ministry of Public Security,Beijing,China [4]Beijing Tongda Shoucheng Institute of Forensic Science,Beijing,China

出　　处：《Journal of Forensic Science and Medicine》2024年第3期255-260,共6页法庭科学与法医学杂志（英文）

基　　金：This work was supported by the Fundamental Research Funds for the Central Universities from China.

摘　　要：X-chromosomal genetic markers are frequently employed in forensic parentage determination owing to their distinctive inheritance patterns.The kinship analysis revealed that two sisters who were not identical twins had identical genotypes on the X chromosome,encompassing 36 X-chromosomal short tandem repeats(X-STRs)and 29 X-chromosomal single-nucleotide polymorphisms(X-SNPs)that spanned the whole X chromosome from the p-telomere to the q-telomere.The identical X-STRs and X-SNPs in the daughters could be the result of linkage or a rare chance of occurrence.This highlights the need for careful analysis and interpretation when dealing with X chromosome markers and that in individual cases,even if two women share an allele at each locus,this does not necessarily mean that they are paternal sisters.The likelihood of random concordance due to maternal alleles must be taken into account.

关 键 词：Linkage disequilibrium recombination short tandem repeats single-nucleotide polymorphisms X chromosome 

分 类 号：Q343.2[生物学—遗传学] D919[医药卫生—法医学]