刺激响应型智能纳米递药系统的研究进展  

Research advances of stimuli-responsive intelligent nanodrug delivery systems

作　　者：王晓迪 雷可心 郭建洋[1] 杨念婉[1,2] 万方浩 吕志创[1] 刘万学[1] WANG Xiao-Di;LEI Ke-Xin;GUO Jian-Yang;YANG Nian-Wan;WAN Fang-Hao;L Zhi-Chuang;LIU Wan-Xue(State Key Laboratory for Biology of Plant Diseases and Insect Pests,Institute of Plant Protection,Chinese Academy of Agricultural Sciences,Beijing 100193,China;Institute of Western Agriculture,Chinese Academy of Agricultural Sciences,Changji 831100,China)

机构地区：[1]中国农业科学院植物保护研究所,植物病虫害综合治理全国重点实验室,北京100193 [2]中国农业科学院西部农业研究中心,昌吉831100

出　　处：《昆虫学报》2024年第9期1275-1288,共14页Acta Entomologica Sinica

基　　金：国家重点研发计划项目(2021YFC2600400,2021YFD1400200,2022YFC2601000);天山英才青年科技拔尖人才专项(2022TSYCCX0084);国家自然科学基金项目(32072494)。

摘　　要：开发高效、绿色农药制剂以最大限度地减少化学残留和环境污染,对于确保粮食和生态安全至关重要。纳米技术的发展为农业绿色农药制剂的创制提供了策略,科研人员设计了一系列针对病虫草害引发的病理环境和体外物理刺激的智能响应型金属或无机纳米载体,该类载体可以通过响应动植物体内pH、活性氧(reactive oxygen species, ROS)、氧化还原条件等内源性变化或者温度、光照等外部刺激,来实现药物的精准可控释放,并提高对病虫草害的防治效率。本文从内源性刺激响应、外源性刺激响应和多重刺激响应3个方面综述了当前农业领域智能响应型纳米递药系统的研究进展,对智能响应型纳米递药系统的功能设计、作用特点及效果进行了介绍,以期为农药/核酸类药物及其递送系统的研究提供参考。未来智能响应型纳米递药系统将会作为一种有前途的方式,提高药剂的利用率,实现药剂的靶向释放。Developing efficient and environmentally friendly pesticide formulations to minimize chemical residues and pollution to the greatest extent possible is critical to ensure food and ecological security.The development of nanotechnology has provided strategies for the creation of green pesticide formulations in agriculture.Researchers have developed a series of intelligent responsive metal or inorganic nanocarriers that target pathological environments and in vitro physical stimuli from diseases,pests and weeds.These carriers can achieve precise-controllable drug release by responding to endogenous changes in animals and plants such as pH,reactive oxygen species(ROS)and redox conditions,or external stimuli such as temperature and light,and improve the efficiency of disease,pest and weed control.From three aspects of responding to endogenous stimuli,responding to exogenous stimuli and responding to multiple stimuli,in this article we reviewed the current status of research on intelligent responsive nano-based drug delivery systems in the agricultural field,introduced the functional design,functional characteristics,and effects of intelligent responsive nanocarriers to serve as a reference for research on pesticides/nucleic acid drugs and their delivery systems.In the future,intelligent responsive nanodrug delivery systems could be a promising vehicle to enhance drug utilization and realize target-specific drug release.

关 键 词：纳米递药系统 智能响应 精准可控释放 内源性刺激 外源性刺激 多重刺激 

分 类 号：Q965[生物学—昆虫学]