中药注射液治疗特发性间质性肺炎的网状Meta分析  

Network Meta-analysis of traditional Chinese medicine injections in treatment of idiopathic interstitial pneumonia

作　　者：马嘉琦 徐才轩 毛果 邓秀娟 李仲普 刘雨 黄乐 管聘 MA Jiaqi;XU Caixuan;MAO Guo;DENG Xiujuan;LI Zhongpu;LIU Yu;HUANG Le;GUAN Pi(Hunan University of Chinese Medicine,Changsha 410208,China;Hunan Provincial Hospital of Integrated Traditional Chinese and Western Medicine,Changsha 410006,China)

机构地区：[1]湖南中医药大学,湖南长沙410208 [2]湖南省中西医结合医院,湖南长沙410006

出　　处：《中草药》2024年第17期5938-5951,共14页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金青年科学基金项目(82004306)。

摘　　要：目的基于网状Meta分析系统评价不同中药注射液治疗特发性间质性肺炎(idiopathic interstitial pneumonia,IIP)的有效性及安全性。方法计算机检索中国知网、万方数据、维普、中国生物医学文献数据库、PubMed、Web of Science、Scopus、EMbase、Cochrane Library数据库的随机对照试验(randomized controlled trial,RCT),时间限定为建库至2024年1月31日,运用Review Manager 5.3、Stata 15进行数据分析。结果最终纳入52项RCTs,涉及17种中药注射液,共计3400例患者,其中试验组1728例,对照组1672例。网状Meta分析显示:①提高临床有效率方面,累积排序曲线下面积(surface under the cumulative ranking curve,SUCRA)排名前3的干预措施为丹红注射液+西医常规、血必净注射液+西医常规、苦参碱注射液+西医常规;②增加用力肺活量(forced vital capacity,FVC)方面,SUCRA排名前3的干预措施为丹参川芎嗪注射液+西医常规、丹红注射液+西医常规、炎琥宁注射液+西医常规;③提高第1秒用力呼气容积百分比(percentage of force expiratory volume in the first second,FEV1%)方面,SUCRA排名前3的干预措施为丹参川芎嗪注射液+西医常规、丹红注射液+西医常规、苦参碱注射液+西医常规;④提高一氧化碳弥散量百分比(percentage of diffused carbon monoxide,DLCO%)方面,SUCRA排名前3的干预措施为参芎葡萄糖注射液+西医常规、川芎嗪注射液+西医常规、红景天注射液+西医常规;⑤提高动脉氧分压(PaO2)方面,SUCRA排名前3的干预措施为红花黄色素氯化钠注射液+西医常规、红景天注射液+西医常规、丹红注射液+西医常规;⑥提高6 min步行试验(6 min walking test,6MWT)方面,SUCRA排名前3的干预措施为丹红注射液+西医常规、痰热清注射液+西医常规、参麦注射液+西医常规;⑦降低转化生长因子-β1(transforming growth factor-β1,TGF-β1)方面,SUCRA排名前2的干预措施为丹红注射液+西医常规、丹参川芎嗪�Objective To evaluate the efficacy and safety of different traditional Chinese medicine injections(TCMIs)in the treatment of idiopathic interstitial pneumonitis(IIP)based on network Meta-analysis.Methods The randomized controlled trials(RCTs)were retrieved from CNKI,Wanfang data,VIP,Chinese Biomedical Literature Database,PubMed,Web of Science,Scopus,Embase,and Cochrane Library databases,with a time limit of database establishment until January 31,2024.Data analysis was conducted using Review Manager 5.3 and Stata 15.Results A total of 52 RCTs were included,involving 17 kinds of TCMIs,with a total sample size of 3400 cases,including 1728 cases in the experimental group and 1672 cases in the control group.Network Meta-analysis revealed:①In terms of improving clinical total effective rate,the top 3 interventions with surface under the cumulative ranking curve(SUCRA)were Danhong Injection(丹红注射液)+western medicine routine,Xuebijing Injection(血必净注射液)+western medicine routine,and Kushenjian Injection(苦参碱注射液)+western medicine routine;②In terms of increasing forceful lung capacity(FVC),the top three interventions with SUCRA were Danshen Chuanxiongqing Injection(丹参川芎嗪注射液)+western medicine routine,Danghong Injection+western medicine routine,and Yanhuning Injection(炎琥宁注射液)+western medicine routine;③In terms of increasing the percentage of force expiratory volume in the first second(FEV1%),the top three interventions with SUCRA were Dashen Chuanxiongqing Injection+western medicine routine,Danhong Injection+western medicine routine,and Kushenjian Injection+western medicine routine;④In terms of increasing the percentage of diffused carbon monoxide(DLCO%),the top three interventions with SUCRA were Shenxiong Glucose Injection(参芎葡萄糖注射液)+western medicine routine,Chuanxiongqin Injection+western medicine routine,Hongjingtian Injection(红景天注射液)+western medicine routine;⑤In terms of increasing the partial pressure of arterial oxygen(PaO2)

关 键 词：特发性间质性肺炎 网状Meta分析 黄芪注射液 参附注射液 参麦注射液 参芎葡萄糖注射液 川芎嗪注射液 刺五加注射液 红景天注射液 丹参多酚注射液 丹红注射液 红花黄色素氯化钠注射液 热毒宁注射液 疏血通注射液 苦参碱注射液 丹参川芎嗪注射液 痰热清注射液 炎琥宁注射液 血必净注射液 

分 类 号：R285.64[医药卫生—中药学]