莪术防治肺部疾病的研究进展  

Research progress on Curcumae Rhizoma in prevention and treatment of pulmonary diseases

作　　者：马定财 王哲 王毛毛 张育贵 辛二旦 边甜甜 窦芬瑜 吕瑞龙 柴梦娜 李越峰 MA Dingcai;WANG Zhe;WANG Maomao;ZHANG Yugui;XIN Erdan;BIAN Tiantian;DOUFenyu;LYU Ruilong;CHAI Mengna;LI Yuefeng(College of Pharmacy,Gansu University of Chinese Medicine,Lanzhou 730000,China;Gansu University of Chinese Medicine Scientific Research and Experimental Center,Lanzhou 730000,China)

机构地区：[1]甘肃中医药大学药学院,甘肃兰州730000 [2]甘肃中医药大学科研实验中心,甘肃兰州730000

出　　处：《中草药》2024年第17期6040-6050,共11页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金资助项目(81960713);国家自然科学基金资助项目(82160750);2024年甘肃省人才重点项目(中药炮制技术传承创新团队建设与示范推广);甘肃省教育厅产业支撑计划项目(2021CYZC-21);甘肃省科学技术厅-科技计划(创新基地与人才计划)基础研究创新群体项目(21JR7RA569);2024年高校产业支撑项目(2024CYZC-41)。

摘　　要：近年来,受生活微环境及复杂因素的影响,肺部疾病的发病率逐年上升,常见的化学药由于不良反应已不能满足临床需求,因此寻找安全有效的药物是目前急需解决的难题。莪术Curcumae Rhizoma具有行气破血、消积止痛的功效。现代研究表明莪术在抗肿瘤、抗病毒、抗炎、抗血栓等方面具有药理活性。其活性成分在治疗病毒性肺炎、急性肺损伤、肺纤维化、慢性阻塞性肺疾病、支气管哮喘、肺癌等肺部疾病疗效突出。通过总结近年来国内外文献发现,莪术活性成分可通过多机制、多靶点防治肺部疾病,通过对莪术防治肺部疾病的作用机制进行总结,为后续研究和临床应用提供思路。In recent years,the incidence of pulmonary diseases has increased year by year due to the living microenvironment and complex factors.The common Western drugs can no longer meet the clinical needs due to side effects and adverse reactions,so it is an urgent problem to find safe and effective drugs.Ezhu(Curcumae Rhizoma)has the effect of promoting qi and breaking blood,relieving accumulation and relieving pain.Modern research shows that Curcumae Rhizoma has pharmacological activities in antitumor,antivirus,anti-inflammation,anti-thrombotic and so on.The active ingredients of Curcumae Rhizoma are effective in treatment of viral pneumonia,acute lung injury,pulmonary fibrosis,chronic obstructive pulmonary disease,bronchial asthma,lung cancer and other lung diseases.By summarizing the literature at home and abroad in recent years,it was found that the active ingredients of Curcumae Rhizoma can prevent and cure pulmonary diseases through multiple mechanisms and targets.In this paper,the mechanism of action of Curcumae Rhizoma in the prevention and cure of pulmonary diseases was summarized to provide ideas for subsequent research and clinical application.

关 键 词：莪术 肺部疾病 莪术油 姜黄素 莪术醇 莪术二酮 吉马酮 Β-榄香烯 

分 类 号：R285[医药卫生—中药学]