丹参活性成分抗肿瘤分子机制研究进展  

Research progress on antitumor molecular mechanism of active ingredient in Salvia miltiorrhiza

作　　者：廖江龙 范子祥 孟秋月 李艳英 王婧斯 LIAO Jianglong;FAN Zixiang;MENG Qiuyue;LIYanying;WANG Jingsi(Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China;Increasepharm(Tianjin)Institnte Co.,Ltd.,Tianjin 300385,China;Beijing Increasepharm Institnte Co.,Ltd.,Beijing 102200,China)

机构地区：[1]天津中医药大学,天津301617 [2]盈科瑞(天津)创新医药研究有限公司,天津300385 [3]北京盈科瑞创新医药股份有限公司,北京102200

出　　处：《中草药》2024年第18期6402-6415,共14页Chinese Traditional and Herbal Drugs

基　　金：西青区专业技术人才“金字塔”培养工程(2019);西青区专业技术人才“金字塔”培养工程(2023);中关村开放实验室成果转化概念验证项目(20220481093)。

摘　　要：恶性肿瘤作为全球第2大死因严重危害着人类生命健康,从天然植物中提取的药物在恶性肿瘤治疗中具有重要作用。现代药理学研究证实,丹参Salvia miltiorrhizae及其活性成分,如丹参酮Ⅱ_(A)、二氢丹参酮、丹参素、丹酚酸B、木犀草素等具有抑制肿瘤细胞增殖、转移和侵袭,诱导肿瘤细胞凋亡、自噬等药理作用。通过总结近几年丹参在抗肿瘤方面的相关文献,对丹参活性成分抗肿瘤的分子机制进行综述,为丹参抗肿瘤作用的深入研究与开发利用提供依据。Malignant tumors,as the second leading cause of death worldwide,pose a serious threat to human life and health.Drugs extracted from natural plants play an important role in the treatment of malignant tumors.Modern pharmacological research has confirmed that some components of Salvia miltiorrhiza and its active ingredients,such as tanshinone II_(A),dihydrotanshinone,danshensu,salvianolic acid B,and luteolin,have pharmacological effects on inhibiting tumor cell proliferation,metastasis,and invasion,inducing tumor cell apoptosis,autophagy,etc.By summarizing the relevant literature on S.miltiorrhiza’s antitumor effects in recent years,and the molecular mechanisms of S.miltiorrhiza’s active ingredients in antitumor effects was reviewed,which could provide a basis for in-depth research and development of S.miltiorrhiza’s antitumor effects.

关 键 词：丹参 丹参酮Ⅱ_(A) 二氢丹参酮 丹参素 丹酚酸B 木犀草素 抗肿瘤 

分 类 号：R285[医药卫生—中药学]