益赛普治疗急性痛风性关节炎的效果及对炎症因子的影响  

Effect of rhTNFR-Ig in the treatment of acute gouty arthritis and the impact on inflammatory factors

作　　者：牛敏[1] 杨西超 马丽娅 原菁蔓 闫美茜 马含晖 武淑芳[2] NIU Min;YANG Xi-chao;MA Li-ya;YUAN Jing-man;YAN Mei-xi;MA Han-hui;WU Shu-fang(Department of Rheumatology Immunology and Endocrinology,Affiliated Honghui Hospital of Xi'an Jiaotong University,Xi'an 710000;Department of Center for Translational Medicine,the First Affiliated Hospital of Xi'an Jiaotong University,Xi'an 710061,Shaanxi,China)

机构地区：[1]西安交通大学附属红会医院风湿免疫内分泌科,陕西西安710000 [2]西安交通大学第一附属医院转化医学中心,陕西西安710061

出　　处：《川北医学院学报》2024年第10期1343-1347,共5页Journal of North Sichuan Medical College

基　　金：陕西省重点研发计划项目(2021SF-074)。

摘　　要：目的:探究益赛普治疗急性痛风性关节炎(AGA)的效果及其对炎症因子的影响。方法:将72例AGA患者按照不同治疗方法分为治疗组(n=37)和对照组(n=35)。对照组接受秋水仙碱治疗;治疗组接受益赛普治疗,比较两组患者视觉模拟评分(VAS)、肿瘤坏死因子α(TNF-α)、血沉(ESR)、C反应蛋白(CRP)、白细胞介素1(IL-1)、IL-2、IL-6、IL-8水平、影像学指标评分、肝功能、肾功能相关指标。结果:治疗1、2、4周后,治疗组VAS评分均低于对照组(P<0.05);治疗后,治疗组TNF-α、ESR、CRP、IL-1、IL-2、IL-6、IL-8水平及影像学指标评分均低于对照组(P<0.05),肝功能、肾功能指标均高于对照组(P<0.05),治疗前后两组尿红细胞(RBC)、尿蛋白(PRO)、血尿酸(UA)、空腹血糖(FBG)、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL)组内、组间均无统计学差异(P>0.05)。结论:益赛普治疗AGA患者能有效改善患者关节疼痛、炎症反应,促进关节修复,临床安全性良好。Objective:To explore the effect of rhTNFR-Ig in the treatment of acute gouty arthritis(AGA)and its impact on inflammatory factors.Methods:According to different treatment methods,72 patients with AGA were divided into treatment group(n=37)and control group(n=35),receiving treatment with colchicine and treatment with rhTNFR-Ig,respectively.The visual analog scale(VAS),tumor necrosis factor-α(TNF-α),erythrocyte sedimentation rate(ESR),C-reactive protein(CRP),interleukin-1(IL-1),IL-2,IL-6,IL-8 levels,imaging index scores,liver function,and kidney function related indicators were compared between the two groups.Results:The VAS scores of the treatment group was lower than that of the control group after 1,2 and 4 weeks of medication(P<0.05).After treatment,the levels of TNF-α,ESR,CRP,IL-1,IL-2,IL-6 and IL-8,and the scores for imaging indicators in the treatment group were lower than those in the control group(P<0.05).Liver function indicators and renal function indicator were higher than those in the control group(P<0.05).There was no significant difference in urine red blood cells(RBC),urine protein(PRO),blood uric acid(UA),fasting blood glucose(FBG),total cholesterol(TC),triglyceride(TG),or low-density lipoprotein(LDL)within the group before and after treatment,nor between groups(P>0.05).Conclusion:rhTNFR-Ig can effectively relieve joint pain and inflammatory response and promote joint restoration in patients with AGA,with good safety.

关 键 词：急性痛风性关节炎 益赛普 疼痛 炎症因子 

分 类 号：R684.3[医药卫生—骨科学]