卤米松与吡美莫司分别联合窄谱UVB治疗小儿面部白癜风疗效比较  

Comparison of efficacy of halometasone or pimecrolimus combined with narrow-band UVB in the treatment of facial vitiligo in children

作　　者：冯丽君 庄绪臻 赵彩红 刘璐 FENG Li-jun;ZHUANG Xu-zhen;ZHAO Cai-hong;LIU Lu(Department of Dermatology,Qingdao Municipal Hospital,Qingdao 266000,Shandong,China;Emergency Center,Qingdao Central Hospital,Qingdao Central Hospital of Rehabilitation University,Qingdao 266000,Shandong,China;Department of Child Health,Qingdao Maternal and Child Health and Family Planning Service Center,Qingdao Municipal Hospital,Qingdao 266000,Shandong,China;Department of East Hospital Pediatrics,Qingdao Municipal Hospital,Qingdao 266000,Shandong,China)

机构地区：[1]康复大学青岛中心医院·青岛市中心医院皮肤科,山东青岛266000 [2]康复大学青岛中心医院·青岛市中心医院急救中心,山东青岛266000 [3]康复大学青岛中心医院·青岛市中心医院青岛市妇幼保健计划生育服务中心儿童保健科,山东青岛266000 [4]康复大学青岛中心医院·青岛市中心医院青岛市市立医院东院儿科,山东青岛266000

出　　处：《川北医学院学报》2024年第10期1386-1389,共4页Journal of North Sichuan Medical College

基　　金：山东省青岛市医药科研指导项目(2020-WJZD021)。

摘　　要：目的:探究卤米松与吡美莫司分别联合窄谱UVB对小儿面部白癜风的疗效。方法:选取104例面部白癜风患儿为研究对象,按照治疗方式不同将患儿分为A组(n=52)与B组(n=52)。A组给予卤米松+窄谱UVB治疗;B组给予吡美莫司+窄谱UVB治疗。比较两组临床疗效、白斑情况、T细胞亚群变化(CD3^(+)T细胞数、CD4^(+)T细胞数、CD8^(+)T细胞数)、氧化应激[丙二醛(MDA)、活性氧(ROS)、谷胱甘肽过氧化物酶(GSH-Px)]、炎症指标差异。结果:治疗后,B组临床疗效高于A组(P<0.05);两组白斑个数及面积、CD8^(+)、MDA、ROS、炎症指标水平均降低(P<0.05),且B组低于A组(P<0.05);CD3^(+)、CD4^(+)、GSH-Px水平均升高(P<0.05),且B组高于A组(P<0.05)。结论:在小儿面部白癜风中,吡美莫司联合窄谱UVB治疗不仅能提高患者临床疗效,还能帮助调节患者T细胞水平,改善氧化应激和炎症反应。Objective:To investigate the efficacy of halometasone or pimecrolimus combined with narrow-band UVB on facial vitiligo in children.Methods:104 children with facial vitiligo were included as the study subjects and divided into group A(n=52)and group B(n=52)by different treatment methods.Group A was given halometasone+narrow-band UVB,whereas group B was given pimecrolimus+narrow-band UVB.The clinical efficacy,white spots,T cell subsets(CD3^(+)T cell count,CD4^(+)T cell count,CD8^(+)T cell count),oxidative stress[malondialdehyde(MDA),reactive oxygen species(ROS),glutathione peroxidase(GSH-Px)]and inflammatory indicators were compared between the two groups.Results:After treatment,the clinical efficacy in group B was higher than that in group A(P<0.05).The number and area of white spots and levels of CD8^(+),MDA,ROS and inflammatory indicators in both groups were decreased(P<0.05),and the above indicators were lower in group B(P<0.05).The levels of CD3^(+),CD4^(+)and GSH-Px were increased in both groups(P<0.05),and the levels in group B were higher(P<0.05).Conclusion:For children with facial vitiligo,pimecrolimus combined with narrow-band UVB treatment can not only enhance the clinical efficacy of patients,but also help regulate the levels of T cells,and improve the oxidative stress and inflammatory response.

关 键 词：小儿面部白癜风 卤米松 吡美莫司 临床疗效 免疫功能 

分 类 号：R758.41[医药卫生—皮肤病学与性病学]