溶血三项及孕妇血清IgG效价检测与新生儿溶血病发病率相关性研究  

Relationship between three hemolysis tests,maternal serum IgG antibody titer detection and the incidence rate of hemolytic direare of newborn

作　　者：刘一霏 任伟娟 赵海卫 LIU Yi-fei;REN Wei-juan;ZHAO Hai-wei(Department of Blood Transfusion,the Second Affiliated Hospital of Xi'an Medical University,Xi'an 710000;Department of Laboratory,No.215 Hospital of Shaanxi Nuclear Industry,Xianyang 712000;Department of Medical Laboratory,Xi'an Qinhuang Hospital,Xi'an 710600,Shaanxi,China)

机构地区：[1]西安医学院第二附属医院输血科,陕西西安710000 [2]陕西省核工业二一五医院检验科,陕西咸阳712000 [3]西安秦皇医院医学检验科,陕西西安710600

出　　处：《川北医学院学报》2024年第10期1399-1402,共4页Journal of North Sichuan Medical College

基　　金：西安医学院第二附属医院科研项目(17KY0225)。

摘　　要：目的:研究溶血三项及孕妇血清IgG效价检测与新生儿溶血病(HDN)发病率的相关性。方法:纳入产检、分娩的90例O型血产妇及其分娩的新生儿作为研究对象,监测孕妇血清IgG抗体效价,采用溶血三项判定新生儿发生HDN与否。结果:溶血三项试验显示,判定ABO-HDN率为16.67%,释放、直抗、游离试验阳性率为100.0%、53.33%%、80.00%。溶血三项均阳性和两项阳性的患儿ABO-HDN发生率均高于单项阳性患儿(P<0.05),A型患儿溶血阳性率高于B型患儿(P<0.05)。随着孕妇血清IgG抗体效价依次增加,ABO-HDN发生率逐渐升高(P<0.05)。Spearman分析显示,孕妇IgG抗体效价与ABO-HDN发病率正相关(r_(s)=0.341,P<0.05)。结论:溶血三项及孕妇血清IgG抗体效价与HDN发病率具有相关性,孕期中应监测血清IgG抗体效价,同时新生儿应检测溶血三项,以早期诊断和治疗HDN。Objective:To study the relationship between three hemolysis tests,maternal serum IgG antibody titer detection and the incidence rate of hemolytic direare of newborn(HDN).Methods:90 cases of parturient women with type O blood and their newborns were included in the parturient examination and delivery.Serum IgG antibody titer of pregnant women was monitored,and hemolysis was used to determine whether newborns developed HDN.Results:Three hemolysis tests showed that the incidence rate of ABO-HDN was 16.67%.The positive rates of release,direct resistance and ionization tests were 100.0%,53.33%and 80.00%.The incidence of ABO-HDN in children with three positive hemolysis and binomial positive hemolysis was higher than that in children with single positive hemolysis(P<0.05),and the hemolysis positive rate in children with type A was higher than that in children with type B hemolysis(P<0.05).The incidence of ABO-HDN gradually increased with the increase of serum IgG antibody titer(P<0.05).Spearman correlation analysis showed that the titer of IgG antibody in pregnant women was positively correlated with the incidence of ABO-HDN(r_(s)=0.341,P<0.05).Conclusion:Three hemolysis test results and maternal serum IgG antibody titer of pregnant women are correlated with the incidence of HDN.Serum IgG antibody titer should be monitored during pregnancy,while hemolysaccharide titer should be detected in newborns for early and treatment of HDN.

关 键 词：溶血三项 血清IgG抗体效价 新生儿溶血病 诊断 

分 类 号：R722.18[医药卫生—儿科]