血清FKN、Copeptin与新生儿感染性肺炎患儿免疫功能与病情的关系  

The Relationship Between Serum FKN,Copeptin and Immune Function and Clinical Condition of Neonatal Infective Pneumonia

作　　者：李烨 刘婷[1] 郑柳[1] 李丽[1] 王芊 徐征 LI Ye;LIU Ting;ZHENG Liu;LI Li;WANG Qian;XU Zheng(Department of Clinical Laboratory,82nd Group Military Hospital,Baoding 071000,China;Department of Clinical Laboratory,Baoding Hospital,Beijing Children's HospitalAffiliated to Capital Medical University,Baoding 071000,China)

机构地区：[1]中国人民解放军陆军第八十二集团军医院检验科,河北保定071000 [2]首都医科大学附属北京儿童医院保定医院检验科,河北保定071000

出　　处：《标记免疫分析与临床》2024年第9期1661-1665,共5页Labeled Immunoassays and Clinical Medicine

基　　金：河北省保定市计划项目(编号:2241ZF359)。

摘　　要：目的探讨分析血清不规则趋化因子(FKN)、和肽素(Copeptin)与新生儿感染性肺炎患儿免疫功能与病情的关系。方法纳入2021年10月至2023年10月我院诊治的新生儿感染性肺炎患儿82例,设为观察组,并纳入同期分娩的80例健康新生儿,作为对照组。入组新生儿均于入院时取其血清样本,采用贝克曼全自动特定蛋白免疫分析仪IMMAGE800检测其血清免疫球蛋白水平,采用酶联免疫吸附法检测血清炎症因子水平以及血清FKN、Copeptin水平,然后采用Spearman相关系数分析水平与患儿免疫功能与病情的关系。结果观察组患儿血清FKN、Copeptin和血清免疫球蛋白A(IgA)、免疫球蛋白G(IgG)、免疫球蛋白M(IgM)、C反应蛋白(CRP)、白细胞介素10(IL-10)、降钙素原(PCT)、白细胞介素17(IL-17)水平高于对照组(P<0.05)。重症患儿血清FKN、Copeptin和血清IgM、IgA、IgG、CRP、IL-10、PCT、IL-17水平高于轻症患儿(P<0.05)。Spearman相关性分析结果显示,血清FKN、Copeptin水平与IgM、IgA、IgG、CRP、PCT、IL-10、IL-17水平呈正相关关系(P<0.05)。结论新生儿感染性肺炎患儿血清FKN、Copeptin水平较高,其水平与患儿免疫功能和病情严重程度呈正相关关系,监测其水平对早期评估患儿病情及免疫功能具有重要参考意义,进而指导临床治疗,提高患儿生命质量。Objective To investigate the relationship between serum irregular chemokine(FKN),Copeptin and immune function and clinical condition of neonatal children with infectious pneumonia.Methods 82 cases of neonatal infectious pneumonia diagnosed and treated in our hospital from October,2021 to October,2023 were included as the observation group.Serum samples were taken from all neonates at admission.Serum immunoglobulin levels were detected by Beckman automatic specific protein immunoanalyzer IMMAGE800.Serum inflammatory factors and serum FKN and Copeptin levels were detected by enzyme-related immunosorbent assay.Spearman correlation coefficient was used to analyze the relationship between detected levels and immune function and clinical condition.Results In the observation group,serum FKN,Copeptin,serum immunoglobulin A(IgA),immunoglobulin G(IgG),immunoglobulin M(IgM),C-reactive protein(CRP),interleukin 10(IL-10),procalcitonin(PCT),and interleukin 17(IL-17)were all higher than those of the control group(P<0.05).The levels of serum FKN,Copeptin,IgM,IgA,IgG,CRP,IL-10,PCT and IL-17 among severe children were all higher than those of mild children(P<0.05).Spearman correlation analysis showed that serum FKN and Copeptin levels were positively correlated with IgM,IgA,IgG,CRP,PCT,IL-10 and IL-17 levels(P<0.05).Conclusion The serum levels of FKN and Copeptin in newborn children with infectious pneumonia are high,and their levels are positively correlated with the immune function and severity of the disease.Monitoring their levels is of great reference significance for the early assessment of the clinical condition and immune function of the children,so as to guide clinical treatment and improve the quality of life.

关 键 词：新生儿感染性肺炎 免疫功能 病情 不规则趋化因子 和肽素 

分 类 号：R722.1[医药卫生—儿科]