重症肺炎合并感染性休克患者联合检测CRP/ALB、NLR、GLI的意义  

Significance of Combined Determination of CRP/ALB,NLR and GLI in Patients with Severe Pneumonia Complicated with Septic Shock

作　　者：周星求 李超锋 李红甜 赖智权 ZHOU Xingqiu;LI Chaofeng;LI Hongtian;LAI Zhiquan(Emergency Department of Xiaolan People's Hospital in Zhongshan City,Zhongshan 528415,China;Intensive Care Unit of Xiaolan People's Hospital in Zhongshan City,Zhongshan 528415,China;Department of Internal Medicine,ChenXinghai Hospital,Zhongshan City,Zhongshan 528415,China)

机构地区：[1]中山市小榄人民医院急诊科,广东中山528415 [2]中山市小榄人民医院重症监护室,广东中山528415 [3]中山市陈星海医院内科,广东中山528415

出　　处：《标记免疫分析与临床》2024年第9期1666-1669,1674,共5页Labeled Immunoassays and Clinical Medicine

基　　金：中山市医学科研项目(编号:2021A020286)。

摘　　要：目的探究C反应蛋白(CRP)/白蛋白(ALB)、中性粒细胞/淋巴细胞比值(NLR)、血糖不稳定指数(GLI)水平变化在重症肺炎患者感染性休克患者中的意义。方法选取2021年9月至2023年9月于我院进行治疗的重症肺炎126例,留取外周血检测CRP、ALB、NLR、GLI。所有患者按照有无感染性休克分为感染性休克组(70例)和未感染性休克组(56例),分析患者一般资料及CRP/ALB、NLR、GLI。将感染性休克患者经过痰培养结果分为革兰阳性菌感染(35例)患者和革兰阴性菌感染性患者(35例),对比CRP/ALB、NLR、GLI水平,并使用Logistic回归分析探讨CRP/ALB、NLR、GLI与感染性休克的关系。结果与未感染性休克组相比,感染性休克组患者年龄>60岁、具有呼吸道疾病、具有糖尿病、吸烟史>10年的占比均较高,差异具有统计学意义(P<0.05);与未感染性休克组相比,感染性休克组患者CRP/ALB、GLI、NLR水平均较高(P<0.05);革兰阳性菌感染患者与革兰阴性菌感染患者的CRP/ALB、GLI、NLR水平比较,差异无统计学意义(P>0.05);Logistic回归分析CRP/ALB、NLR、GLI水平与发生感染性休克独立相关(P<0.05)。结论在重症肺炎感染性休克中CRP/ALB、GLI、NLR水平均较高,通过检测CRP/ALB、GLI、NLR水平,有助于为后续治疗转归提供重要参考。Objective To investigate the significance of C-reactive protein(CRP)/albumin(ALB),neutrophil/lymphocyte ratio(NLR)and glycemic instability index(GLI)in septic shock in patients with severe pneumonia.Methods 126 cases of severe pneumonia treated in our hospital from September 2021 to September 2023 were selected,and peripheral blood samples were collected to detect CRP,ALB,NLR and GLI.All the patients were divided into septic shock group(70 cases)and non-septic shock group(56 cases)according to whether there was septic shock or not.The general data and CRP/ALB,NLR and GLI of the patients were analyzed.The sputum culture results of septic shock patients were divided into gram-positive bacteria infection patients(35 cases)and gram-negative bacteria infection patients(35 cases).The levels of CRP/ALB,NLR and GLI were compared,and the relationship between CRP/ALB,NLR and GLI and septic shock was discussed by Logistic regression analysis.Results Compared with the non-septic shock group,the age of patients>60 years old,respiratory disease,diabetes,smoking history>10 years in septic shock group were higher,the difference was statistically significant(P<0.05).Compared with the non-septic shock group,the level of CRP/ALB,GLI and NLR were higher in septic shock group(P<0.05).There was no significant difference in CRP/ALB,GLI and NLR between gram-positive bacteria infection patients and gram-negative bacteria infection patients(P>0.05).Logistic regression analysis showed that CRP/ALB,NLR and GLI were independently correlated with septic shock(P<0.05).Conclusion CRP/ALB,NLR and GLI levels wer high in septic shock in severe pneumonia,and the detection of detection of CRP/ALB,GLI and NLR levels was helpful to provide an important reference for subsequent treatment outcomes.

关 键 词：重症肺炎手术 中性粒细胞 淋巴细胞 C反应蛋白 白蛋白 血糖不稳定指数 

分 类 号：R563.1[医药卫生—呼吸系统]