支气管哮喘合并肺炎支原体感染患儿血清Periostin、sIL-2R水平变化及其与血清炎症因子、肺功能相关性分析  

Changes of Serum Periostin and sIL-2R Levels in Children with Bronchial Asthma Complicated with Mycoplasma Pneumoniae Infections and Their Correlations with Serum Inflammatory Factors and Lung Function

作　　者：耿在富 王秀萍[1] 王江鹏[1] GENG Zaifu;WANG Xiuping;WANG Jiangpeng(Department of Pediatrics,Yan’an People’s Hospital,Yan’an 716000,China)

机构地区：[1]延安市人民医院儿科,陕西延安716000

出　　处：《标记免疫分析与临床》2024年第9期1675-1679,共5页Labeled Immunoassays and Clinical Medicine

摘　　要：目的探究支气管哮喘合并肺炎支原体(MP)感染患儿血清骨膜蛋白(Periostin)、可溶性白细胞介素-2受体(sIL-2R)水平变化及其与血清炎症因子、肺功能的相关性。方法选择2021年9月至2023年9月本院收治的支气管哮喘合并MP感染患儿(感染组)、单纯支气管哮喘患儿(哮喘组)及同期体检的健康儿童(对照组)各60例。采用酶联免疫吸附法检测血清Periostin、sIL-2R水平。采用Pearson相关性分析支气管哮喘合并MP患儿血清Periostin、sIL-2R水平与炎症因子、肺功能的相关性。结果感染组、哮喘组、对照组血清Periostin、sIL-2R水平均依次降低(P<0.05)。感染组、哮喘组、对照组血清干扰素(IFN)-γ、白细胞介素(IL)-4、IL-8、肿瘤坏死因子(TNF)-α水平均依次降低(P<0.05)。感染组、哮喘组第1秒用力呼气容积(FEV1)/用力肺活量(FVC)均低于对照组(P<0.05);感染组、哮喘组、对照组最大呼气流量(PEF)依次升高(P<0.05)。支气管哮喘合并MP感染患儿血清Periostin、sIL-2R水平均与IFN-γ、IL-4、IL-8、TNF-α水平呈正相关,均与PEF呈负相关(P<0.05)。结论支气管哮喘合并MP感染患儿血清Periostin、sIL-2R水平较高,与患儿血清炎症因子、肺功能密切相关。Objective To investigate changes of serum periostin and soluble interleukin-2 receptor(sIL-2R)levels in children with bronchial asthma complicated with Mycoplasma pneumoniae(MP)infections,and to further evaluate their correlations with serum inflammatory factors and lung function.Methods A total of 60 children with bronchial asthma combined with MP infections(infection group),children with simple bronchial asthma(asthma group)and healthy children(control group)who underwent physical examination during the same period were selected respectively from our hospital from September,2021 to September,2023.Enzyme linked immunosorbent assay(ELISA)method was applied to detect serum levels of Periostin and sIL-2R.Pearson correlation analysis was applied to evaluate the correlation between serum Periodin and sIL-2R levels with inflammatory factors and lung function in children with bronchial asthma complicated with MP infection.Results Serum levels of Periostin and sIL-2R in the infection group,asthma group,and control group were all decreased sequentially(P<0.05).Levels of serum interferon(IFN)-γ,IL-4,IL-8,and tumor necrosis factor(TNF)-αwere decreased sequentially in the infection group,asthma group,and control group(P<0.05).The forced expiratory volume in the first second(FEV1)/forced vital capacity(FVC)in the infection and asthma groups were lower than those in the control group(P<0.05).The maximum expiratory flow(PEF)of the infection group,asthma group,and control group were increased sequentially(P<0.05).Serum levels of Periostin and sIL-2R in children with bronchial asthma complicated with MP infection were positively correlated with IFN-γ,IL-4,IL-8,and TNF-αlevels,while negatively correlated with PEF(P<0.05).Conclusion Children with bronchial asthma complicated with MP infection have higher levels of serum Periodin and sIL-2R,which can be closely related to serum inflammatory factors and lung function.

关 键 词：支气管哮喘 肺炎支原体感染 骨膜蛋白 可溶性白细胞介素-2受体 炎症因子 肺功能 

分 类 号：R562.25[医药卫生—呼吸系统]