2023年北京市朝阳区5家哨点医院呼吸道多病原监测分析  

Analysis of respiratory multi-pathogen monitoring in 5 sentinel hospitals in Chaoyang district,Beijing in 2023

作　　者：张士尧[1] 路冉 王媛杰 王海滨[1] 赵剑虹[1] 孙灵利[1] Zhang Shiyao;Lu Ran;Wang Yuanjie;Wang Haibin;Zhao Jianhong;Sun Lingli(Department ofMicrobial Inspection,Beijing Chaoyang District Center for Disease Control and Prevention,Beijing,100021,China)

机构地区：[1]北京市朝阳区疾病预防控制中心微生物检验科,北京100021

出　　处：《实用医技杂志》2024年第8期533-538,共6页Journal of Practical Medical Techniques

基　　金：首都卫生发展科研专项(2022-1G-4231)。

摘　　要：目的分析2023年北京市朝阳区5家哨点医院呼吸道多病原监测结果,及时掌握朝阳区呼吸道感染性疾病的流行特征。方法收集2023年1月至12月北京市朝阳区5家哨点医院1321例呼吸道患者,所有患者均采集咽拭子,使用多重荧光定量聚合酶链反应(PCR)进行检测甲型流感病毒、季节性甲3型流感病毒、新型甲型H1N1流感病毒、乙型流感病毒、乙型流感病毒BV系、乙型流感病毒BY系、新冠病毒N基因、新冠病毒ORF1ab基因、肺炎支原体、呼吸道合胞病毒、腺病毒、鼻病毒、副流感1型、副流感2型、副流感3型、副流感4型、人偏肺病毒、肠道病毒、冠状病毒HKU1、冠状病毒229E、冠状病毒OC43、冠状病毒NL63和肺炎衣原体。结果多病原检查结果显示,单一病原检测阳性标本633例,复合感染(≥2种病原体)检出76例。不同性别患者病原检出率相比较差异均无统计学意义(P>0.05);不同年龄患者腺病毒、呼吸道合胞病毒、肺炎支原体、新型冠状病毒、乙型流感病毒BV系、季节性甲3型流感病毒和人偏肺病毒相比较差异有统计学意义(P<0.05);不同季度鼻病毒、人偏肺病毒、肠道病毒和副流感2型检出率相比较差异无统计学意义(P>0.05),其他病原检出率相比较差异有统计学意义(P<0.05)。不同季节间年龄构成比相比较差异有统计学意义(P<0.05)。不同病例类型冠状病毒229E、季节性甲3型流感病毒、乙型流感病毒BV系和腺病毒检出率相比较差异有统计学意义(P<0.05),均容易引发急性上呼吸道感染。结论2023年北京市朝阳区呼吸道感染患者,病原检出率前5位是季节性甲3型流感病毒、肺炎支原体、呼吸道合胞病毒、新冠病毒和腺病毒,性别对病原检出率无显著影响,病原检出具有明显的年龄、季度和病例类型等相关特征。Objective To analyze the surveillance results of respiratory multiple pathogens in five sentinel hospitals in Chaoyang district of Beijing in 2023 and to grasp the epidemic characteristics of respiratory infectious diseases in Chaoyang district.Methods A total of 1321 patients who underwent pathogen monitoring at 5 sen-tinel hospitals in Chaoyang District,Beijing,from January to December 2023 were collected as the study subjects,and throat swabs were collected from all patients.Multiple fluorescent quantitative PCR was used to detect in-fluenza A,seasonal influenza A H3,new influenza A H1N1,influenza B,influenza B BV,influenza B BY,2019-nCoV N gene,2019-nCoV ORF1ab gene,mycoplasma pneumoniae,respiratory syncytial virus,adenovirus,rhi-novirus,parainfluenza 1,parainfluenza 2,parainfluenza 3,parainfluenza 4,human metapneumonic virus,en-terovirus,coronavirus HKU1,coronavirus 229E,coronavirus OC43,coronavirus NL63 and chlamydia pneumoniae.Results The results of the multi pathogen examination showed that 633 patients(50.84%)were detected with one pathogen.76 were detected with multiple pathogens(≥2 pathogens).There was no statistically significant differ-ence in the detection rate of pathogens among patients of different genders(P>0.05).There were statistically sig-nificant differences between different ages in adenovirus,respiratory syncytial virus,mycoplasma pneumoniae,2019-nCoV,influenza B BV,seasonal influenza A H3,and human metapneumonic virus(P<0.05).There were no statistical difference in the detection rates of rhinovirus,human metapneumonic virus,enterovirus and parainfluenza 2 in different seasons(P>0.05),but there was a statistical difference in the detection rates of other pathogens in different seasons(P<0.05).There was statistically significant difference in the age composition ratio between different seasons(P<0.05).There was statistically significant difference in the detection rates of different types of cases,including coronavirus 229E,seasonal influenza A H3,influenza B BV,and adenovirus(P<0.05).Con

关 键 词：呼吸道感染 哨点监测 病原菌 北京市朝阳区 

分 类 号：R446.5[医药卫生—诊断学]