面向微流控芯片工作状态感知的智能泵:设计、实现和验证  

Design, Implementation, and Validation of an Intelligent Pump for Microfluidic Chip State Perception

作　　者：刘国镪 方策 肖林 赖永康[1,3] 张东旭 LIU Guoqiang;FANG Ce;XIAO Lin;LAI Yongkang;ZHANG Dongxu(School of Public Health,Xiamen University,Xiamen,Fujian 361102;Discipline of Intelligent Instruments and Equipment Department,Xiamen University,Xiamen,Fujian 361102;National Institute of Diagnostics and Vaccine Development in Infectious Diseases,Xiamen University,Xiamen,Fujian 361102)

机构地区：[1]厦门大学公共卫生学院,福建厦门361102 [2]厦门大学智能仪器与装备学科,福建厦门361102 [3]厦门大学国家传染病诊断试剂与疫苗工程技术研究中心,福建厦门361102

出　　处：《液压与气动》2024年第10期150-157,共8页Chinese Hydraulics & Pneumatics

基　　金：内蒙古重点研发和成果转化计划(2023YFDZ0060);横向资助项目(校合20223160A0463)。

摘　　要：针对微流控芯片内部流体状态实时预测和工作流程调控的需求,提出了一种基于“驱动器即传感器”理念的智能泵。对所提出智能泵系统工作原理和工作流程进行介绍,并对测试微流控芯片及工作状态预测需求进行分析。建立压力信号处理流程,气压信号经预处理后,提取有效时域特征,进行状态预测训练。进行微流控芯片工作状态验证,实验表明:智能泵预测磁珠球复溶结果和冻干球复溶结果与实际测量和生物实验结果相一致,验证了智能泵系统的有效性。An intelligent pump based on the concept of“actuator-as-sensor”is proposed to meet the requirements of real-time prediction of internal fluid state and workflow control in microfluidic chip.The proposed intelligent pump system,working principle,and workflow are introduced,and the requirements for testing microfluidic chip and state prediction are analyzed.A pressure signal processing process is established,after processing the pressure signal,effective time-domain features are extracted for state prediction training.Verification experimentals on the working status of the microfluidic chip are conducted,and the experimentals show that the predicted results of magnetic bead ball redissolution and freeze dried ball redissolution by the intelligent pump are consistent with the actual measurement and biological experimental results,verifying the effectiveness of the intelligent pump system.

关 键 词：智能泵 微流控芯片 信号处理 状态感知 

分 类 号：TH138[机械工程—机械制造及自动化]