丹参活性成分防治心力衰竭药理作用研究进展  

Research progress on pharmacological effects of active components of Salvia miltiorrhiza in prevention and treatment of heart failure

作　　者：张冠雄 耿晓娟 田露[3] 王作顺[4] ZHANG Guanxiong;GENG Xiaojuan;TIAN Lu;WANG Zuoshun(Graduate School,Tianjin University of Chinese Medicine,Tianjin 301636,China)

机构地区：[1]天津中医药大学研究生院,301636 [2]天津中医药大学文化与健康传播学院 [3]天津中医药大学中医学院 [4]天津市中医药研究院附属医院心病科

出　　处：《环球中医药》2024年第10期2088-2095,共8页Global Traditional Chinese Medicine

基　　金：国家中医药管理局科技局《中华医藏经典医籍影校对照整理丛书》专项立项(GZY-KJS 2021-061)。

摘　　要：丹参活性成分通过抑制磷脂酰肌醇3-激酶/蛋白激酶B信号通路激活,阻止转化生长因子β(transforming growth factor β,TGF-β)/Smad信号通路激活,抑制细胞外调节蛋白激酶(extracellular regulatory protein kinase, ERK)1/2-GATA结合蛋白4信号通路,抑制基质金属蛋白酶的激活,下调半乳糖凝集素-3的表达,抑制血管紧张素/转化生长因子/骨膜蛋白信号通路,调控激活素A/卵泡抑素系统,抑制Ras信号通路,减轻心肌纤维化,延缓心脏重构。丹参活性成分通过抑制Toll受体/髓样分化因子/肿瘤坏死因子受体相关因子/核因子κB信号通路激活,减轻心肌炎症反应。丹参活性成分通过恢复氧化和抗氧化的平衡,调节核因子E_(2)相关因子2/丝裂原活化蛋白激酶信号通路,减轻氧化应激反应,降低心肌氧化损伤。丹参活性成分通过阻断NOD样受体家族蛋白3炎症小体形成,激活沉默信息调节器1信号通路,激活死亡域相关蛋白/丝裂原激活蛋白激酶/细胞外调节蛋白激酶1/2通路,调节凋亡相关蛋白的分泌,促进c-Jun氨基末端激酶/ERK信号通路,抑制TGF-β1信号通路,降低心肌细胞凋亡,发挥心脏保护作用。丹参活性成分通过调节腺苷酸活化蛋白激酶/哺乳动物雷帕霉素靶蛋白通路,增强细胞自噬,以促进心脏修复。丹参活性成分通过降低心房颤动,发挥抗心衰作用。Active components of Salvia miltiorrhiza inhibit the activation of PI3K/Akt signaling pathway,prevent the activation of TGF-β/Smad signaling pathway,inhibit ERK1/2-GATA4 signaling pathway,inhibit the activation of matrix metalloproteinases,down-regulate the expression of galectin-3,and inhibit ANG-TGF-PN signaling pathway.Active components of Salvia miltiorrhiza can regulate activin A/folliclestatin system,inhibit Ras signaling pathway,reduce myocardial fibrosis and delay cardiac remodeling.Active components of Salvia miltiorrhiza reduce myocardial inflammation by inhibiting the activation of TLR/Myd88/TRAF/NF-κB signaling pathway.Active components of Salvia miltiorrhiza can regulate Nrf2/MAPK signaling pathway by restoring the balance of oxidation and antioxidant,alleviating oxidative stress reaction and reducing oxidative damage of myocardium.By blocking the formation of NLPR3 inflammasome,active components of Salvia miltiorae activate can regulate the silent-information regulator 1 signaling pathway,activate the death domain associated protein MEK/ERK1/2 pathway,regulate the secretion of apoptosis-related proteins,promote the JNK/ERK signaling pathway,and inhibit TGF-β1 signaling pathway.Active components of Salvia miltiorrhiza can reduce cardiomyocyte apoptosis and play a role in cardiac protection.Active components of Salvia miltiorrhiae can enhance autophagy by regulating AMPK-mTOR pathway to promote cardiac repair.Active components of Salvia miltiorrhiza play an anti-heart failure role by reducing atrial fibrillation.

关 键 词：丹参 心力衰竭 药理作用 丹参酮 丹酚酸 心肌纤维化 细胞凋亡 细胞自噬 心房颤动 

分 类 号：R285[医药卫生—中药学]