Interventional pulmonology for chronic inflammatory airway diseases  

作　　者：Han Yang Si Chen Jiayuan Sun Felix J.F.Herth 

机构地区：[1]Department of Respiratory and Critical Care Medicine,Shanghai Chest Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200030,China [2]Department of Respiratory Endoscopy,Shanghai Chest Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200030,China [3]Shanghai Engineering Research Center of Respiratory Endoscopy,Shanghai 200030,China [4]Pneumology and Critical Care Medicine,Thoraxklinik,University of Heidelberg,Heidelberg 69126,Germany [5]Translational Lung Research Center Heidelberg,German Center for Lung Research,Heidelberg 69126,Germany

出　　处：《Chinese Medical Journal Pulmonary and Critical Care Medicine》2024年第3期171-181,共11页呼吸与危重症医学（英文）

基　　金：supported by the Science and Technology Commission of Shanghai Municipality(Nos.22S31901300 and 23440790103);Shanghai Innovative Medical Device Application Demonstration Project 2023(No.23SHS02600).

摘　　要：Chronic inflammatory airway diseases,such as chronic bronchitis,chronic obstructive pulmonary disease,emphysema,and bronchial asthma,pose significant healthcare challenges.Interventional treatments offer promise as valuable complements to the optimal medical therapy recommended by the Global Initiative for Chronic Obstructive Lung Disease guideline and the Global Initiative for Asthma guideline.By directly accessing the airways,these minimally invasive procedures enable precise interventions.They encompass a wide range of techniques including bronchial thermoplasty and targeted lung denervation for both chronic obstructive pulmonary disease and severe asthma,bronchoscopic lung volume reduction(including the use of endobronchial valves,coils,and bronchoscopic thermal vapor ablation),airway bypass and peripheral stent placement for emphysema,bronchial rheoplasty and spray cryotherapy for chronic bronchitis,and other emerging methods.These interventional treatments aim to improve patients’symptoms by reducing lung volume,alleviating hyperinflation,eliminating vagal innervation,disrupting hyperplastic goblet cells and thus reducing excessive mucus secretion,and weakening submucosal smooth muscles.This review highlights the potential advantages of interventional treatments for chronic inflammatory airway diseases and discusses relevant techniques tailored to specific disease subtypes.The overall aim is to assist interventional pulmonologists in selecting the most appropriate techniques for individual patients.

关 键 词：Chronic inflammatory airway disease Chronic obstructive pulmonary disease ASTHMA EMPHYSEMA Bronchoscopic lung volume reduction Targeted lung denervation 

分 类 号：R56[医药卫生—呼吸系统]