Mimicking Mytilus edulis foot protein:A versatile strategy for robust biomedical coatings  

作　　者：Zeyu Du Feng Qiao Liping Tong Wentai Zhang Xiaohui Mou Xin Zhao Manfred FMaitz Huaiyu Wang Nan Huang Zhilu Yang 

机构地区：[1]School of Materials Science and Engineering,Department of Cardiology,Third People’s Hospital of Chengdu Affiliated with Southwest Jiaotong University,Southwest Jiaotong University,Chengdu 610031,China [2]Dongguan Key Laboratory of Smart Biomaterials and Regenerative Medicine,The Tenth Affiliated Hospital of Southern Medical University,Dongguan 523059,China [3]Institute of Biomedicine and Biotechnology,Shenzhen Institute of Advanced Technology,Chinese Academy of Sciences,Shenzhen 518055,China [4]Department of Biomedical Engineering,The Hong Kong Polytechnic University,Hung Hom,Hong Kong,China [5]Max Bergmann Center of Biomaterials Dresden,Leibniz Institute of Polymer Research Dresden,Hohe Strasse 6,01069 Dresden,Germany [6]The Key Laboratory of Biomedical Imaging Science and System,Chinese Academy of Sciences,Shenzhen 518055,China [7]GuangZhou Nanchuang Mount Everest Company for Medical Science and Technology,Guangzhou 510670,China

出　　处：《The Innovation》2024年第5期73-82,72,共11页创新（英文）

基　　金：supported by the National Natural Science Foundation of China(projects 82072072,32171326,82272157,32261160372,and 82350710800);the Guangdong Basic and Applied Basic Research Foundation(2022B1515130010 and 2021A1515111035);the National Natural Science Foundation of China/Research Grants Council(NSFC/RGC)Joint Research Scheme(N_PolyU526/22);the Leading Talent Project of Guangzhou Development District(2020-L013)。

摘　　要：Universal coatings with versatile surface adhesion,good mechanochemical robustness,and the capacity for secondary modification are of great scientific interest.However,incorporating these advantages into a system is still a great challenge.Here,we report a series of catechol-decorated polyallylamines(CPAs),denoted as pseudo-Mytilus edulis foot protein 5(pseudoMefp-5),that mimic not only the catechol and amine groups but also the backbone of Mefp-5.CPAs can fabricate highly adhesive,robust,multifunctional polyCPA(PCPA)coatings based on synergetic catechol-polyamine chemistry as universal building blocks.Due to the interpenetrating entangled network architectures,these coatings exhibit high chemical robustness against harsh conditions(HCl,pH 1;NaOH,pH 14;H2O2,30%),good mechanical robustness,and wear resistance.In addition,PCPA coatings provide abundant grafting sites,enabling the fabrication of various functional surfaces through secondary modification.Furthermore,the versatility,multifaceted robustness,and scalability of PCPA coatings indicate their great potential for surface engineering,especially for withstanding harsh conditions in multipurpose biomedical applications.

关 键 词：WEAR CATECHOL VERSATILE 

分 类 号：R318[医药卫生—生物医学工程]