Characterization of a New HIV-1 Circulating Recombinant Form CRF142_BC—Yunnan,China,2015 and 2021  

作　　者：Min Chen Huichao Chen Shouxiong Lei Jie Dai Yanling Ma Manhong Jia 

机构地区：[1]Yunnan Provincial Key Laboratory of Public Health and Biosafety&Health Laboratory Center,Yunnan Center for Disease Control and Prevention,Kunming City,Yunnan Province,China [2]Institute for AIDS/STD Control and Prevention,Yunnan Center for Disease Control and Prevention,Kunming City,Yunnan Province,China [3]Division for AIDS/STD Control and Prevention,Zhaotong Center for Disease Control and Prevention,Zhaotong City,Yunnan Province,China [4]Yunnan Provincial Key Laboratory of Public Health and Biosafety&Institute for AIDS/STD Control and Prevention,Yunnan Center for Disease Control and Prevention,Kunming City,Yunnan Province,China

出　　处：《China CDC weekly》2024年第42期1080-1085,共6页中国疾病预防控制中心周报（英文）

基　　金：Supported by the National Natural Science Foundation of China(82160635);the Yunnan Revitalization Talents Support Program(Special Project for Famous Doctors).

摘　　要：What is already known about this topic?Recombinant strains dominate the human immunodeficiency virus 1(HIV-1)epidemic in China.Yunnan Province was the first region in China to report HIV-1 infections in batches.The long-term HIV-1 epidemic led to the generation of various recombinant forms.Among the 47 circulating recombinant forms(CRFs)reported in China,more than 20 were first identified in Yunnan Province.What is added by this report?This study reported a previously unrecognized HIV-1 CRF(CRF142_BC)characterized by the insertion of four short subtype B fragments into the subtype C backbone.CRF142_BC was estimated to have emerged in the mid-1990s,close to the time of the emergence of most known CRF_BCs in China.What are the implications for public health practice?The discovery of new CRFs will provide a basis for HIV-1 molecular tracing and intervention research.In addition,HIV-1 recombination can alter viral biological properties.The study of HIV-1 gene variants needs to be intensified.

关 键 词：properties. China. intensified 

分 类 号：R512.91[医药卫生—内科学]