血浆D-二聚体和纤维蛋白降解产物联合检测在弥散性血管内凝血中的临床意义  

Clinical significance of combined detection of plasma D-dimer and fibrin degradation products in disseminated intravascular coagulation

作　　者：毕菲 Bi Fei(Department of Clinical Laboratory,Jinxiang County People's Hospital,Jining 272200,Shandong,China)

机构地区：[1]金乡县人民医院检验科,山东济宁272200

出　　处：《实用检验医师杂志》2024年第3期242-245,共4页Chinese Journal of Clinical Pathologist

摘　　要：目的探讨血浆D-二聚体和纤维蛋白原降解产物(FDP)联合检测在弥散性血管内凝血(DIC)中的临床意义。方法选择2022年1月—2023年1月至金乡县人民医院检测的120例确诊DIC患者作为研究对象,纳入观察组;另外选择同期120例健康体检者纳入对照组。采用免疫比浊法检测两组D-二聚体和FDP水平,分析D-二聚体和FDP单独与联合检测的诊断敏感度、准确度、特异度。结果观察组血浆D-二聚体和FDP水平均显著高于对照组〔D-二聚体(mg/L):7.13±1.21比0.36±0.10;FDP(mg/L):12.32±2.75比4.66±1.14;均P<0.05〕。D-二聚体和FDP联合检测的敏感度、准确度、特异度均显著高于单独检测(敏感度:100.00%比73.33%、76.67%;准确度:100.00%比70.83%、75.00%;特异度:100.00%比68.33%、73.33%;均P<0.05)。结论对DIC患者进行血浆D-二聚体和FDP联合检测可提高诊断效能,降低漏诊率和误诊率,为疾病的诊疗提供可靠依据,便于临床采纳并推广。Objective To investigate the clinical significance of combined detection of plasma D-dimer and fibrinogen degradation products(FDP)in disseminated intravascular coagulation(DIC).Methods The 120 patients diagnosed with DIC who were tested in Jinxiang County People's Hospital from January 2022 to January 2023 were included in observation group,and 120 healthy examiners during the same period were included in control group.The levels of D-dimer and FDP in two groups were detected using immunoturbidimetry.The diagnostic sensitivity,accuracy and specificity of D-dimer,FDP alone and combined detection were analyzed.Results The plasma levels of D-dimer and FDP in observation group were significantly higher than those in control group[D-dimer(mg/L):7.13±1.21 vs.0.36±0.10;FDP(mg/L):12.32±2.75 vs.4.66±1.14;both P<0.05].The sensitivity,accuracy and specificity of D-dimer and FDP combined detection were significantly higher than those detected alone(sensitivity:100.00%vs.73.33%,76.67%;accuracy:100.00%vs.70.83%,75.00%;specificity:100.00%vs.68.33%,73.33%;all P<0.05).Conclusion Plasma D-dimer and FDP detection for patients with DIC is convenient to improve their diagnostic efficiency,reduce the leakage rate and misdiagnosis rate,provide reliable diagnostic data for the diagnosis and treatment of diseases,and facilitate clinical adoption and promotion.

关 键 词：弥散性血管内凝血 血浆D-二聚体 纤维蛋白原降解产物 联合检测 

分 类 号：R554.8[医药卫生—血液循环系统疾病] R446.1[医药卫生—内科学]