Inhibiting scar formation via wearable multilayer stacked electret patch:Self-creation of persistent and customizable DC electric field for fibrogenic activity restriction  

作　　者：Sung-Won Kim Sumin Cho Donghan Lee Jiyu Hyun Sunmin Jang Inwoo Seo Hyun Su Park Hee Jae Hwang Hyung-Seop Han Dae Hyeok Yang Heung Jae Chun Suk Ho Bhang Dongwhi Choi 

机构地区：[1]School of Chemical Engineering,Sungkyunkwan University,Suwon,Republic of Korea [2]Department of Mechanical Engineering(Integrated Engineering Program),Kyung Hee University,Yongin,Gyeonggi,Republic of Korea [3]Biomaterials Research Center,Biomedical Research Division,Korea Institute of Science and Technology(KIST),Seoul,Republic of Korea [4]Department of Medical Life Sciences,College of Medicine,Institute of Cell and Tissue Engineering,The Catholic University of Korea,Seoul,Republic of Korea

出　　处：《InfoMat》2024年第3期66-80,共15页信息材料（英文）

基　　金：National Research Foundation of Korea(NRF),Grant/Award Numbers:2021R1A4A1032782,2022R1C1C1008831;Korean Fund for Regenerative Medicine(KFRM),Grant/Award Number:21A0102L1-12;Postdoctoral Research Program of Sungkyunkwan University。

摘　　要：Electrical stimulation has recently received attention as noninvasive treatment in skin wound healing with its outstanding biological property for clinical setting.However,the complexity of equipment for applying appropriate electrical stimulation remains an ongoing challenge.Here,we proposed a strategy for skin scar inhibition by providing electrical stimulation via a multilayer stacked electret(MS-electret),which can generate direct current(DC)electric field(EF)without any power supply equipment.In addition,the MS-electret can easily control the intensity of EFs by simply stacking electret layers and maintain stable EF with the surface potential of 3400 V over 5 days owing to the injected charges on the electret surface.We confirmed inhibition of type 1 collagen andα-SMA expression of human dermal fibroblasts(hDFs)by 90%and 44%in vitro,indicating that the transition of hDFs to myofibroblasts was restricted by applying stable electrical stimulation.We further revealed a 20%significant decrease in the ratio of myofibroblasts caused by the MS-electret in vivo.These findings present that the MS-electret is an outstanding candidate for effective skin scar inhibition with a battery-free,physiological electrical microenvironment,and noninvasive treatment that allows it to prevent external infection.

关 键 词：DC electric field dermal fibroblasts ELECTRET scar formation restriction self-creation of electrical stimulation 

分 类 号：TM721.1[电气工程—电力系统及自动化]