Urotensin-I suppresses the hypothalamo-hypophyseal-ovarian axis in the Mozambique tilapia,Oreochromis mossambicus  

作　　者：Jyoti A.Kumbar C.B.Ganesh 

机构地区：[1]Neuroendocrinology Research Laboratory,Department of Studies in Zoology,Karnatak University,Dharwad,580003,India

出　　处：《Aquaculture and Fisheries》2024年第3期339-346,共8页渔业学报（英文）

基　　金：supported by a grant from Science and Engineering Research Board-Department of Science and Technology(No.EEQ/2017/414) and New Delhi,Government of India.

摘　　要：Urotensin-I(UI)is a peptide belonging to the corticotropin-releasing hormone family,produced in the urophysis of teleosts.This investigation was undertaken to examine the effect of UI on the hypothalamo-hypophyseal-ovarian axis in the Mozambique tilapia,a cichlid fish.In the first experiment,administration of UI(2μg/100μL saline)for 22 days caused a significant reduction in the number of follicles at stages I,II,III(previtellogenic),IV(vitellogenic),and V(preovulatory),concomitant with a significant increase in the percent atresia of follicles at stages II,III,and IV than in controls.In the pituitary,gonadotropin-releasing hormone(GnRH)-positive fibres were detected in the proximal pars distalis(PPD)in both controls and UI-treated fish;however,there was a significant reduction in the intensity and percent area of GnRH-immunoreactive fibres in fish treated with UI compared with controls.The serum luteinizing hormone(LH)level was significantly lower,whereas a significant rise in the serum level of cortisol was noticed in UI-treated fish compared with controls.In the second experiment,treatment with a low dose of UI(10 mM)did not affect the number of ACTH-secreting cells in vitro,but the number of these cells was significantly higher in high-dose UI(50 mM)-treated pituitaries compared to controls.Together,the present investigation reveals for the first time that the treatment of UI affects the follicular development process through the downregulation of the GnRH-LH axis and activation of the pituitary-interrenal pathway in teleosts.

关 键 词：Urotensin-I CRH family Gonadotropin-releasing hormone Luteinizing hormone OVARY Oreochromis mossambicus 

分 类 号：S965.125[农业科学—水产养殖]