NO transport characteristics in microcirculation and its implications in the assessment of microvascular dysfunction in type 2 diabetes mellitus  

作　　者：Ying He Yongtao Liu Lili Long Yajie Wei Yunxia Lu 

机构地区：[1]Key Laboratory of Ocean Energy Utilization and Energy Conservation of Ministry of Education,Dalian University of Technology,116023 Dalian,China [2]School of Energy and Power Engineering,Dalian University of Technology,116023 Dalian,China [3]School of Basic Medical Sciences,Anhui Medical University,230032 Hefei,China

出　　处：《Medicine in Novel Technology and Devices》2024年第3期44-58,共15页医学中新技术与新装备（英文）

基　　金：supported by National Natural Science Foundation of China(NSFC No 51576033,51976026);Dalian Innovative Funding of Science and Technology(No.2018J12SN076);the Fundamental Research Funds for the Central Universities(DUT20GJ203,DUT22YG206).

摘　　要：Diabetes mellitus is a metabolic disorder syndrome caused by various pathogenic factors leading to imbalance of active substance secretion and endothelial dysfunction,causing macro and micro vascular complications.As the most important signal transduction molecule released by endothelium,NO participates in various physiological processes of microcirculation and plays an important role in vascular relaxation regulation.Extensive studies focus on the investigation of the analysis of NO transport in microvessels,RBC motion and its influence on NO transport since they are of extremely importance for understanding the mechanisms of vessel autoregulation and microcirculation lesion.NO transport characteristics are closely associated with hemorheology,hemodynamics and microvascular structure.Nevertheless,up to date,there are limited reports on NO transport characteristics in diabetic mellitus.The purpose of this review is to summarize the current advances in the investigation of NO transport characteristics from cellular to vascular level,which can provide effective ideas for the early diagnosis of vascular complications in diabetes.

关 键 词：MICROCIRCULATION MELLITUS MICROVASCULAR 

分 类 号：R587.1[医药卫生—内分泌]