维持血液透析并发获得性反应性穿通性胶原病二例并文献复习  

Acquired reactive penetrating collagenosis in patients treated with maintenance hemodialysis:two cases report and literature review

作　　者：郑林 莫友[1] 李倩 思远 佘浠宁 白靖竹 唐奕 李群[1] 方锐华[1] ZHENG Lin;MO You;LI Qian;SI Yuan;SHE Xining;BAI Jingzhu;TANG Yi;LI Qun;FANG Ruihua(Department of Dermatology,Guangzhou First People's Hospital,Guangzhou 510180,China)

机构地区：[1]广州市第一人民医院皮肤科,广东广州510180

出　　处：《中国麻风皮肤病杂志》2024年第12期866-869,共4页China Journal of Leprosy and Skin Diseases

基　　金：广州市科技计划项目(编号:2024A04J3784)。

摘　　要：获得性反应性穿通性胶原病(ARPC)通常与多种系统性疾病相关。本文报道2例血液透析的患者发生ARPC。患者1,自血液透析后开始出现面部丘疹,渐蔓延至全身,瘙痒明显;患者2,透析13年后出现全身丘疹和瘙痒症状,两例患者均经实验室检查和皮肤组织病理学检查确诊为ARPC。治疗上患者1起初给予抗组胺治疗,效果不佳,后改为度普利尤单抗治疗,皮疹消退;患者2给予口服氯雷他定、外用糖皮质激素软膏治疗,皮疹消退。Acquired reactive perforating collagenosis(ARPC)is usually associated with a variety of systemic diseases.We report two cases with ARPC undergoing hemodialysis.For patient 1,facial papules began to appear after hemodialysis and gradually spread throughout the body,with obvious pruritus;for patient 2,systemic papules and pruritus occurred 13 years after dialysis.Both patients were diagnosed with ARPC through laboratory tests and skin histopathological examinations.In terms of treatment,patient 1 was initially given antihistamine treatment,but the effect was not good.Later,dupilumab treatment was changed,and the rash subsided;patient 2 was given oral loratadine and topical glucocorticoid ointment treatment,and the rash subsided.

关 键 词：血液透析 获得性反应性穿通性胶原病 度普利尤单抗 

分 类 号：R692.5[医药卫生—泌尿科学] R758.6[医药卫生—外科学]