阿达木单抗联合糖皮质激素治疗复发难治性坏疽性脓皮病一例  

Relapsed and refractory pyoderma gangrenosum treated with a combination of adalimumab and glucocorticoids:a case report

作　　者：孙建林 韩建文[1] 乌日嘎[1] SUN Jianlin;HAN Jianwen;WU Riga(Department of Dermatology,Affiliated Hospital of Inner Mongolia Medical University,Hohhot 010000,China)

机构地区：[1]内蒙古医科大学附属医院皮肤科,内蒙古呼和浩特010000

出　　处：《中国麻风皮肤病杂志》2024年第12期884-886,共3页China Journal of Leprosy and Skin Diseases

基　　金：内蒙古自治区自然科学基金项目面上项目(编号:2020MS08112);内蒙古医科大学面上项目(编号:YKD2021MS039)。

摘　　要：本文报道一例患有坏疽性脓皮病17年的患者,该患者先后18次于我科住院治疗,曾使用糖皮质激素、免疫抑制剂、益赛普、沙利度胺等药物及物理治疗,皮肤溃疡可好转,但仍有反复。半月前患者病情加重,给予糖皮质激素联合阿达木单抗治疗,2周后溃疡变浅出院。出院后口服甲泼尼龙50 mg每日1次,逐渐减量,阿达木单抗40 mg,每2周1次,第4次注射阿达木单抗后溃疡大部分愈合。随访8个月,患者已停用糖皮质激素,阿达木维持治疗,皮损基本痊愈。We report a case of a patient with pyoderma gangrena for 17 years.The patient has been hospitalized in our department for 18 times.He has been treated with glucocorticoids,immunosuppressants,esepil,thalidomide and other drugs and physical therapy,and the skin ulcer can be improved,but there are still repeated.The patient's condition worsened half a month ago,and he was treated with glucocorticoid combined with adalimumab.After 2 weeks,the ulcer became shallow and he was discharged.After discharge,methylprednisolone 50 mg was taken orally once a day and gradually reduced,and adalimumab 40 mg was taken orally once every 2 weeks.Most of the ulcers healed after the fourth injection of adalimumab.After 8 months of follow-up,the patient had stopped taking glucocorticoid,maintained treatment with adalimumab,and the skin lesions were basically cured.

关 键 词：坏疽性脓皮病 阿达木单抗 糖皮质激素 

分 类 号：R751[医药卫生—皮肤病学与性病学]