久坐间断对成年人血管功能的急性影响与调节因素:荟萃分析  

Acute effects and moderators of sedentary interruption on vascular function in adults:a Meta-analysis

作　　者：殷明越 刘骞 许雄壮 马智英 邓盛基 邓鉴峰 黎涌明 Yin Mingyue;Liu Qian;Xu Xiongzhuang;Ma Zhiying;Deng Shengji;Deng Jianfeng;Li Yongming(School of Athletic Performance,Shanghai University of Sport,Shanghai 200438,China;School of Physical Education,Sichuan Agricultural University,Yaan 625014,Sichuan Province,China;Institute of Sport Science,School of Physical Education,Southwest University,Chongqing 400715,China;School of Exercise and Health,Shanghai University of Sport,Shanghai 200438,China;School of Human Science,University of Western Australia,Perth,Australia;National Research Institute of Sports Science,Beijing 100061,China)

机构地区：[1]上海体育大学竞技运动学院,上海市200438 [2]四川农业大学体育学院,四川省雅安市625014 [3]西南大学体育学院体育科学研究所,重庆市400715 [4]上海体育大学运动健康学院,上海市200438 [5]西澳大利亚大学人文科学学院,珀斯 [6]国家体育总局体育科学研究所,北京市100061

出　　处：《中国组织工程研究》2025年第17期3684-3696,共13页Chinese Journal of Tissue Engineering Research

摘　　要：目的:持续性地久坐行为会急性降低外周与中枢血管功能,进而加剧罹患心血管疾病风险。久坐间断可能是预防持续久坐对血管功能危害的潜在实用策略,但目前关于其急性功效的已有研究结论并不一致,也尚未得出具体的应用建议。文章旨在对久坐间断对成人外周与中枢血管功能的急性影响进行荟萃分析,并探究其调节因素。方法:基于PRISMA报告规范,以“interrupting”“sedentary”与“vascular function”等为文献检索特征词,于2024年3月检索Web of Science核心合集、PubMed和中国知网数据库。纳入久坐间断对成人外周与中枢血管功能的急性影响的急性随机交叉试验文献。基于Cochrane开发的Risk of Bias 2评估偏倚风险,并基于GRADE系统评价证据等级。使用R语言(版本4.2.0)中的“meta”与“metafor”包进行主效应合并(Hedge’s g作为效应量指标)、发表偏倚检验、亚组与回归分析。结果:纳入22篇随机交叉试验,共364例受试者(年龄21-70岁)。相比于持续不间断久坐,久坐间断急性提升外周血管血流量(Hedge’s g=0.48,95%CI:0.14-0.82,P<0.01,I2=63%,低证据等级)、剪切应力(Hedge’s g=0.65,95%CI:0.37-0.93,P<0.01,I^(2)=54%,中等证据等级)与血流介导的血管舒张功能(Hedge’s g=0.43,95%CI:0.15-0.72,P<0.01,I2=61%,中等证据等级)。疾病(亚组间P=0.01)与性别(亚组间P=0.01)对血流量的主效应合并有显著调节作用(亚组间P=0.01),间断方式(亚组间P=0.01)与频率(亚组间P=0.02)对剪切应力的主效应合并有显著调节作用。久坐间断改善外周血管剪切应力受年龄(β=-0.02,95%CI:-0.03-0.01,P=0.09)与体质量指数(β=-0.10,95%CI:-0.18至-0.02,P<0.01)影响。久坐间断改善血流介导的血管舒张功能受总间断次数(β=-0.09,95%CI:-0.17至-0.01,P=0.03)与试验期间久坐控制时长影响(β=-0.21,-0.34至-0.09,P<0.01);每增加1 h久坐时长与久坐间断对血流介导的血管舒张功能的急性提升�OBJECTIVE:Prolonged sedentary behavior can acutely reduce peripheral and central vascular function,thereby increasing the risk of cardiovascular disease.Interrupting sedentary behavior may be a potential practical strategy to prevent vascular dysfunction caused by prolonged sitting.However,current research findings on its acute effects are inconsistent,and specific application recommendations have not yet been established.This study aims to perform a Meta-analysis on the acute effects of interrupting sedentary behavior on peripheral and central vascular function in adults and to explore its regulatory factors.METHODS:Following PRISMA reporting guidelines,literature search was conducted in March 2024 using the keywords of“interrupting,”“sedentary,”and“vascular function”in the Web of Science Core Collection,PubMed,and China National Knowledge Infrastructure(CNKI)databases.Acute randomized crossover trials addressing the acute effects of interrupting sedentary behavior on peripheral and central vascular function in adults were included.Risk of Bias 2 developed by Cochrane was used to assess bias risk,and the Grading of Recommendations Assessment,Development,and Evaluation(GRADE)system was used to evaluate the evidence level.The“meta”and“metaphor”packages in R(version 4.2.0)were used for main effect aggregation(Hedge’s g acted as the effect size indicator),publication bias testing,subgroup analysis,and regression analysis.RESULTS:Twenty-two randomized crossover trials involving 364 subjects(aged 21 to 70 years)were included.Meta-analysis results showed that compared with prolonged sitting,interrupting sedentary behavior acutely improved peripheral vascular blood flow volume(Hedge’s g=0.48,95%confidence interval:0.14-0.82,P<0.01,I²=63%,low evidence level),shear stress(Hedge’s g=0.65,95%confidence interval:0.37-0.93,P<0.01,I^(2)=54%,moderate evidence level),and flow-mediated dilation(Hedge’s g=0.43,95%confidence interval:0.15-0.72,P<0.01,I²=61%,moderate evidence level).Disease had a signif

关 键 词：久坐间断 久坐行为 碎片化运动 血流介导的血管舒张功能 血管功能 血流量 剪切应力 中枢血管功能 荟萃分析 Meta分析 

分 类 号：R459.9[医药卫生—治疗学] R318[医药卫生—临床医学] R87