高热惊厥病因和治疗的研究进展  

Research Progress on the Etiology of Febrile Seizures and the Treatment

作　　者：郝雪南 杨磊 赵文雅 张炜 HAO Xue-nan;YANG Lei;ZHAO Wen-ya;ZHANG Wei(Institute of Integrated Traditional Chinese and Western Medicine,Hebei Medical University,Shijiazhuang,050017,China)

机构地区：[1]河北医科大学中西医结合研究所,石家庄050017

出　　处：《神经药理学报》2024年第4期42-48,共7页Acta Neuropharmacologica

基　　金：国家重点研发计划“中医药现代化”重点专项(No.2022YFC3500501);国家自然科学基金项目(No.81872848);河北省自然科学基金项目(No.H2022206211);神经与血管生物学教育部重点实验室主任基金项目(No.NV20230002)。

摘　　要：高热惊厥(febrile seizures,FS)是指体温高于或等于38.5℃且无中枢神经系统感染及其它癫痫病因的惊厥,FS的全球总人群发病率为2%~14%,是儿童时期常见的神经系统疾病之一,也是惊厥最常见的原因。FS具有年龄依赖性,多见于6个月至5岁的儿童。目前FS的发病机制仍不清楚,但已知多种因素可诱发FS的发生,如体温异常、年龄和脑成熟程度、遗传因素等。此外,感染和其他因素也可诱发FS的发生。目前FS的治疗主要抗癫痫药物为主,该文通过分析FS的病理生理学机制,重点总结了FS病因和治疗的研究进展。Febrile seizures(FS)are convulsions characterized by a body temperature of 38.5℃or higher,without central nervous system infection or other epileptic causes,affecting 2%to 14%of the global population and being a common neurological disorder in childhood.The occurrence of FS is age dependent,most prevalent in children aged 6 months to 5 years.The pathogenesis of FS remains unclear,although it is known that various factors can induce FS,including abnormal body temperature,age and brain maturity,genetic factors,and infections.Moreover,other factors can predispose to the development of FS.Current treatment of FS primarily involves antiepileptic drugs.This article reviews the pathophysiological mechanisms of FS,with a focus on the research progress of FS etiology and treatment.

关 键 词：高热惊厥 癫痫 炎症 治疗 病因 

分 类 号：R964[医药卫生—药理学]