伤害性感受器与免疫系统在疼痛中交互作用及机制的研究进展  

Research Progress on the Interaction Mechanism Between Nociceptors and Immunity in Pain

作　　者：李雅莉 司绍梦 韩方龙 辛悦阳 徐卉[1] Li Yali;Si Shaomeng;Han Fanglong(Department of Anesthesiology and Pain Medicine,Hubei Key Laboratory of Geriatric Anesthesia and Perioperative Brain Health,and Wuhan Clinical Research Center for Geriatric Anesthesia,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China;Department of Anesthesiology,Xiang yang Maternal and Child Health Hospital,Xiang yang 441003,China)

机构地区：[1]华中科技大学同济医学院附属同济医院麻醉学与疼痛医学科,老年麻醉与围术期脑健康湖北省重点实验室,武汉市老年麻醉临床医学研究中心,武汉430030 [2]湖北省襄阳市妇幼保健院麻醉科,襄阳441003

出　　处：《华中科技大学学报（医学版）》2024年第5期687-692,共6页Acta Medicinae Universitatis Scientiae et Technologiae Huazhong

基　　金：湖北陈孝平科技发展基金会基金资助项目(No.CXPJJH12000005-07-45);襄阳市科技局2022年医疗卫生领域科技计划项目(No.2022YL46B)。

摘　　要：伤害性感受器广泛分布于身体的不同部位,以检测有害刺激并传递疼痛感受,伤害性感受器与免疫系统之间的相互作用近年来备受关注。免疫细胞和炎症因子促进了伤害性感受器的激活和痛觉传递,反之,伤害性感受器也参与调节机体的免疫功能,二者之间的平衡有利于机体在伤害性刺激和感染的情况下进行自我保护。此外,这种神经-免疫的互作也可能是痛觉过敏与炎症并存以及互相促进的基础。该文对不同部位的伤害性感受器与免疫系统的互作在疼痛中的作用及潜在分子机制进行综述,以期为开拓疼痛治疗的新策略提供思路和理论基础。Nociceptive sensory neurons are widely distributed throughout various parts of the body to detect harmful stimuli and transmit pain sensations.In recent years,the interactions between nociceptive sensory neurons and the immune system have garnered increasing attention from researchers.Immune cells and inflammatory factors promote the activation of nociceptors and the transmission of pain;conversely,nociceptors also participate in regulating the body's immune functions.The balance between these two systems is beneficial for self-protection under harmful stimuli and infection.Moreover,this neuroimmune interaction may underlie the coexistence and mutual promotion of hyperalgesia and inflammation.This review primarily discusses the role of interactions between nociceptors in various body regions and the immune system in pain,as well as the potential molecular mechanisms involved.This study aims to provide insights and theoretical foundations for developing new strategies for pain management.

关 键 词：伤害性感受器 免疫 疼痛 炎症 

分 类 号：R402[医药卫生—临床医学]