糖尿病哑铃健身操对早期糖尿病肾病治疗效果及炎症因子的影响  

Effects of diabetes dumbbell fitness exercises on the treatment effect and inflammatory factors of early diabetic nephropathy

作　　者：吴红艳 刘新亮 何加芹 鲁蕊 魏琼[2] WU Hongyan;LIU Xinliang;HE Jiaqin;LU Rui;WEI Qiong(Department of Endocrinology,Xuyi People's Hospital,Yangzhou University Clinical Hospital,Huai'an 223022,China;Department of Endocrinology,Zhongda Hospital Affiliated to Southeast University,Nanjing 210009,China)

机构地区：[1]扬州大学临床医院盱眙人民医院内分泌科,江苏淮安223022 [2]东南大学附属中大医院内分泌科,江苏南京210009

出　　处：《东南大学学报（医学版）》2024年第5期677-683,共7页Journal of Southeast University(Medical Science Edition)

基　　金：淮安市卫生健康科研项目(HAWJ202128)。

摘　　要：目的:探讨糖尿病哑铃健身操对早期糖尿病肾病的治疗效果以及对炎症因子的调控作用,为早期糖尿病肾病患者制定合理的运动治疗模式提供参考。方法:选取2022年1月至2022年12月在盱眙人民医院内分泌科收治的早期糖尿病肾病患者,按照入选标准选取60例患者,根据SAS 9.4软件生成的随机数字表,分为照组和试验组,各30例。对照组接受常规治疗,试验组在常规治疗的基础上进行糖尿病哑铃健身操锻炼。治疗6个月后,比较两组糖脂代谢指标、肾功能指标和炎症因子水平。结果:对照组和试验组治疗后的血糖、血脂、肾功能指标均低于治疗前(P<0.05),且试验组降低更显著(P<0.05)。两组患者治疗后的白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)及单核细胞趋化蛋白-1(MCP-1)水平均显著低于治疗前(P<0.05),且试验组降低更显著(P<0.05)。结论:糖尿病哑铃健身操应用于早期糖尿病肾病患者的治疗中,有助于改善患者的血糖、血脂和肾功能,并能进一步下调炎症因子水平,疗效显著,值得临床推广。Objective:To investigate the therapeutic effect of diabetes dumbbell fitness exercises on early diabetic nephropathy and the modulating effect of inflammatory factors,and to provide a reasonable mode of exercise therapy for patients with early diabetic nephropathy.Methods:Patients with early diabetic nephropathy admitted to the Department of Endocrinology of Xuyi People's Hospital from January 2022 to December 2022 were selected according to the inclusion criteria,and 60 patients were divided into the control group(n=30)and the experimental group(n=30)according to the randomized numerical table generated by SAS 9.4 software.The control group received conventional treatment,while the experimental group underwent diabetes dumbbell fitness exercises on the basis of conventional treatment.After 6 months of treatment,the two groups were compared in terms of glycolipid metabolism indexes,renal function indexes and inflammatory factor levels.Results:After treatment,the blood glucose,blood lipids and renal function indexes of the control group and the experimental group were lower than those before treatment(P<0.05),and the experimental group reduced more significantly(P<0.05);the levels of inflammatory factors of interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),and monocyte chemotactic protein-1(MCP-1)of the two groups were all significantly lower than those before treatment(P<0.05),and the reduction was more significant in the experimental group(P<0.05).Conclusion:Diabetes dumbbell fitness exercises in the treatment of patients with early diabetic nephropathy can help to improve the blood glucose lipids and renal function of patients,and can further lower the level of inflammation factors,which is significant and worthy of clinical promotion.

关 键 词：糖尿病哑铃健身操 糖尿病肾病 血糖 血脂 肾功能 炎症因子 

分 类 号：R587.2[医药卫生—内分泌]