血清AMH、INHB联合经阴道彩超对IVF-ET助孕患者助孕成功的预测价值  

Predictive value of serum AMH,INHB combined with transvaginal color Doppler ultrasound for pregnancy outcomes on IVF-ET assisted pregnancy patients

作　　者：毛剑 尚琴琴 朱丽[3] 吕双军 刘何利 MAO Jian;SHANG Qinqin;ZHU Li;L Shuangjun;LIU Heli(Department of Ultrasound,Hebei Cangzhou Integrated Traditional Chinese and Western Medicine Hospital,Cangzhou 061000,China;Department of Reproductive Medicine,Hebei Cangzhou Integrated Traditional Chinese and Western Medicine Hospital,Cangzhou 061000,China;Department 1 of Ultrasound,Hebei Cangzhou Integrated Traditional Chinese and Western Medicine Hospital,Cangzhou 061000,China;Department of Physical Examination,Hebei Cangzhou Integrated Traditional Chinese and Western Medicine Hospital,Cangzhou 061000,China)

机构地区：[1]河北省沧州中西医结合医院超声科,河北沧州061000 [2]河北省沧州中西医结合医院生殖医学科,河北沧州061000 [3]河北省沧州中西医结合医院超声一科,河北沧州061000 [4]河北省沧州中西医结合医院体检科,河北沧州061000

出　　处：《东南大学学报（医学版）》2024年第5期711-716,共6页Journal of Southeast University(Medical Science Edition)

基　　金：河北省2022年度医学科学研究课题计划项目(20220682)。

摘　　要：目的:探讨体外受精-胚胎移植(IVF-ET)助孕患者血清中抗苗勒氏管激素(AMH)、抑制素B(INHB)联合经阴道彩超预测患者助孕成功的价值。方法:收集本院2019年1月至2023年1月期间进行IVF-ET助孕的160例患者作为研究对象,根据是否助孕成功将其分为未妊娠组(n=86)和妊娠组(n=74)。比较两组血清AMH、INHB水平和阴道彩超结果;ROC曲线分析血清AMH、INHB联合经阴道彩超对IVF-ET助孕患者助孕成功的预测价值;多因素Logistic回归分析IVF-ET助孕患者助孕成功的影响因素。结果:与妊娠组相比,未妊娠组获卵数、AMH、INHB显著降低(P<0.05)。阴道彩超检查结果显示,未妊娠组子宫内膜厚度显著厚于妊娠组(P<0.05)。ROC曲线显示,AMH、INHB、阴道彩超三者联合预测IVF-ET助孕患者助孕成功的AUC为0.956,敏感性为95.35%,特异性为83.78%,优于AMH、INHB、阴道彩超各自单独预测(Z_(联合检测-AMH)=4.543,Z_(联合检测-INHB)=3.733,Z_(联合检测-子宫内膜厚度)=4.511,均P<0.001)。多因素Logistic回归分析结果显示,获卵数、AMH、INHB、子宫内膜厚度是IVF-ET助孕患者助孕成功的影响因素(P<0.05)。结论:血清AMH、INHB联合经阴道彩超对IVF-ET助孕患者是否成功妊娠具有一定的预测价值。Objective:To explore the value of serum anti Mullerian hormone(AMH)and inhibin B(INHB)combined with transvaginal ultrasound in predicting pregnancy outcomes in patients undergoing in vitro fertilization and embryo transfer(IVF-ET)assisted pregnancy.Methods:A total of 160 patients who underwent IVF-ET assisted pregnancy in our hospital from January 2019 to January 2023 were regarded as research subjects.They were separated into non pregnant group(n=86)and pregnant group(n=74)based on pregnancy outcomes.The serum AMH,INHB levels,and vaginal ultrasound results of the two groups were compared;ROC curve was applied to analyze the predictive value of serum AMH,INHB combined with transvaginal ultrasound for pregnancy outcomes in IVF-ET assisted patients;Multivariate Logistic regression was used to analyze the influencing factors of pregnancy outcomes in patients undergoing IVF-ET.Results:Compared with the pregnant group,the number of oocytes retrieved,AMH and INHB levels in the non pregnant group were significantly reduced(P<0.05).The results of vaginal ultrasound examination showed that the thickness of endometrium in the non pregnant group was significantly higher than that in the pregnant group(P<0.05).ROC curve showed that the AUC of AMH,INHB combined with vaginal ultrasound to predict the pregnancy outcome of IVF-ET assisted pregnancy patients was 0.956,with a sensitivity of 95.35%and a specificity of 83.78%,which was better than AMH,INHB,and vaginal ultrasound alone(Z_(combined detection-AMH)=4.543,Z_(combined detection-INHB)=3.733,Z_(combined detection-endometrial thickness)=4.511,all P<0.001).Multivariate Logistic regression analysis showed that the number of oocytes retrieved,AMH,INHB levels and endometrial thickness were the influencing factors of pregnancy outcomes in patients with IVF-ET.Conclusion:Serum AMH,INHB combined with transvaginal ultrasound has certain predictive value for IVF-ET assisted pregnancy patients.

关 键 词：抗苗勒氏管激素 抑制素B 阴道彩色超声 体外受精-胚胎移植 助孕 

分 类 号：R714.8[医药卫生—妇产科学]