Phytocompounds and lipid-based drug delivery system for neurodegenerative diseases  

作　　者：Cennet Ozay Merve Karpuz 

机构地区：[1]Department of Basic Pharmaceutical Sciences,Faculty of Pharmacy,Izmir Katip Celebi University,35620,Izmir,Turkey [2]Department of Radiopharmacy,Faculty of Pharmacy,Izmir Katip Celebi University,35620,Izmir,Turkey

出　　处：《Asian Pacific Journal of Tropical Biomedicine》2024年第10期417-426,共10页亚太热带生物医学杂志（英文版）

摘　　要：Across the annals of time,organic molecules sourced from nature have found innumerable uses within the realms of healthcare,pharmaceuticals,and the study of living organisms.This abundant source of natural compounds has exhibited immense promise in the cure of diverse ailments,mainly neurodegenerative diseases owing to their minimum toxic and adverse effects.However,different challenges exist with phytocompounds from plants such as poor permeation,poor solubility(water/lipid),unsteadiness under extremely acidic pH conditions,and lack of targeting specificity.Furthermore,as a result of the existence of blood-brain barrier membrane and inconvenient pharmacokinetics characteristics of phytocompounds,their passage into the brain is constrained.In order to address this issue and augment the transportation of medications into the brain at a therapeutically effective level,it is imperative to formulate an innovative and pragmatic strategy.Many papers have shown that nanoformulations containing phytocompounds(resveratrol,quercetin,ferulic acid,curcumin,berberine,etc.)effectively improved many neurodegenerative diseases such as Parkinson’s,Alzheimer’s and Huntington’s diseases.This study provides an overview of phytocompounds that are used in nanosized lipid drug delivery systems.These systems are categorized according to lipid types and preparation techniques used in the formulation.Some studies regarding these systems and phytocompounds are also summarized.

关 键 词：Neurodegenerative diseases Phytocompounds Lipid-based drug delivery systems Phytosomes Liposomes Solidlipid nanoparticles Emulsions 

分 类 号：R284.1[医药卫生—中药学]