纳米纤维基智能创伤敷料的研究进展  

Recent Progress of Smart Wound Dressings Based on Nanofibers

作　　者：周美玲 杜姗[1] 欧康康 代云玲 齐琨[1] 王华平[2] ZHOU Meiling;DU Shan;OU Kangkang;DAI Yunling;QI Kun;WANG Huaping(Advanced Textile Equipment Technology Co-construction Collaborative Innovation Center,Zhongyuan University of Technology,Zhengzhou 451191,China;State Key Laboratory for Modification of Chemical Fibers and Polymer Materials,Donghua University,Shanghai 201620,China;School of Textiles and Fashion,Shanghai University of Engineering Science,Shanghai 201620,China)

机构地区：[1]中原工学院先进纺织装备技术省部共建协同创新中心,郑州451191 [2]东华大学纤维材料改性国家重点实验室,上海201620 [3]上海工程技术大学纺织服装学院,上海201620

出　　处：《材料导报》2024年第20期272-282,共11页Materials Reports

基　　金：国家自然科学基金(52003048);河南省高等学校重点科研项目(23A540001,22A540002);中国纺织工业联合会科技指导项目(2021020);中原工学院优势学科实力提升计划项目(SD202219,SD202221,SD202222);中原工学院青年自然科学基金项目(K2022QN013);中原工学院青年骨干教师项目(2021XQG02)。

摘　　要：针对当前创面修复的高需求和现代商业敷料发展不充分之间的矛盾,通过敷料的实时监测、感染预警和按需给药功能来减轻患者痛苦、加速创面愈合成为亟待解决的问题。基于纳米纤维的特性及其在创伤修复中起到的关键作用,围绕纳米纤维基智能创伤敷料的制备及响应体系,阐述了纳米纤维基智能创伤敷料的制备方法、创面微环境标志物监测体系以及敷料自响应药物缓释体系等多个领域的研究进展。最后,从理想敷料的特性、生物相容性、多功能监测和远程医疗等方面,探讨了未来纳米纤维基智能创伤敷料面临的挑战和发展趋势。In view of the contradiction between the current high demand for wound repair and the insufficient development of contemporary commercial dressings,it is expected to alleviate the pain of patients and accelerate wound healing through real-time monitoring,infection warning and on-demand administration of dressings.Based on the characteristics of nanofibers and their key role in wound repair,the preparation and response system of nanofiber-based intelligent wound dressings are reviewed.The preparation methods of nanofiber-based intelligent wound dres-sings,the detection system of wound microenvironment markers and the self-responsive drug delivery system of dressings are described.Finally,the future challenges and development trends of nanofiber-based smart wound dressings are discussed from the perspectives of the characteristics and biocompatibility of ideal dressings,as well as multifunctional monitoring and telemedicine.

关 键 词：纳米纤维 静电纺丝 创伤敷料 智能监测 智能给药 

分 类 号：TS101.4[轻工技术与工程—纺织工程]