高效液相色谱-电感耦合等离子体质谱法测定水蛭药材中11种重金属元素  

Determination of 11 Heavy Metal Elements in Medicinal Leeches by ICP-MS

作　　者：林芳 周金彩[1] 何蓉[1] 刘芳 颜晓维[1] 朱跃芳 陈珉珉 LIN Fang;ZHOU Jincai;HE Rong;LIU Fang;YAN Xiaowei;ZHU Yuefang;CHEN Minmin(Hunan Vocational College of Science and Technology,Hunan Changsha 410200;Zhuzhou Institutes for Food and Drug Control,Hunan Zhuzhou 412000,China)

机构地区：[1]湖南科技职业学院,湖南长沙410200 [2]株洲市食品药品检验所,湖南株洲412000

出　　处：《广州化工》2024年第20期72-74,共3页GuangZhou Chemical Industry

基　　金：湖南省教育厅科学研究项目(23C0683);湖南科技职业学院科研项目(KJ21231)。

摘　　要：采用微波消解法联合ICP-MS法,以钪、锗、铟、铋为内标元素,采用KED模式对样品中重金属元素的含量进行测定,建立电感耦合等离子体质谱法(ICP-MS)同时测定水蛭药材中11种重金属元素的含量。数据显示11种重金属元素具有良好的线性关系,线性系数(r)均大于0.999 0,重复性测试RSD小于2.8%,精密度测试RSD为0.86%~4.0%,回收率为85.2%~110.0%。结果表明本法简单高效、精密度佳、准确性好,可为水蛭药材中11种重金属元素的测定提供技术参考。The microwave digestion combined with ICP-MS was used with Sc,Ge,In and Bi as the internal standard elements,and KED pattern was used to determine the contents of heavy metal elements,in order to establish a method for the determination of 11 heavy metal elements in medicinal leeches by inductively coupled plasma mass spectrometry(ICP-MS).Data displayed totally 11 heavy metal elements all had a good linear relationship and the linear coefficients(r)were greater than 0.9990.The RSDs for repeatability test were less than 2.8%,and those for precision test were 0.86%~4.0%,and the recoveries were between 85.2%and 110.0%.The results showed that the method was simple,rapid and accurate with high sensitivity,which could provide reference for the determination of 11 heavy metal elements in medicinal leeches.

关 键 词：水蛭 高效液相色谱-电感耦合等离子体质谱法 重金属 

分 类 号：R927.1[医药卫生—药学]