基于创新能力培养的8-羟基喹啉合成实验教学改革与实践  

Teaching Reform and Practice on Synthesis of 8-hydroxyquinoline

作　　者：张涛 李冬春 杜振亭 余瑞金 耿会玲 ZHANG Tao;LI Dongchun;DU Zhenting;YU Ruijin;GENG Huiling(College of Chemistry&Pharmacy,Northwest Agricultural&Forestry University,Shaanxi Yangling 712100,China)

机构地区：[1]西北农林科技大学化学与药学院,陕西杨凌712100

出　　处：《广州化工》2024年第20期177-180,共4页GuangZhou Chemical Industry

基　　金：陕西本科教育教学改革研究重点项目(No:23BZ008);陕西省“十四五”教学科学规划课题(No:SGH23Y2232);陕西省教师教育改革与教师发展研究项目(No:SJS2023YB026);西北农林科技大学教育教学改革研究项目(No:JY2301005、JY2103230);西北农林科技大学研究生教改项目(No:JXGG2151、JXGG22057)。

摘　　要：在剖析8-羟基喹啉常见合成方法优缺点的基础上,综合考虑实验条件及反应效率,结合基础性和综合性研究两方面的教学要求,选择Skraup环化合成法和超强酸催化法合成了8-羟基喹啉,采用水蒸气蒸馏或柱色谱分离技术对产物进行纯化,以较高产率获得了产物。上述改革拓展了教学内容,改进了教学方式,加强了实验教学与科学研究、生产实际的结合,夯实了学生的理论知识,提升了实验技能,开阔了知识视野,培养了科学思维,提高了创新能力。On the basis of analyzing the advantages and disadvantages of the popular synthetic protocols of 8-hydroxyquinoline,considering the experimental conditions and reaction efficiency comprehensively,combined with the teaching requirements of basic and comprehensive research,8-hydroxyquinoline was prepared by the method of Skraup cyclization reaction and superacid catalyzed reaction.The coarse product was purified by steam distillation or column chromatography,then the product was achieved with high yield.On the one hand,the reform above mentioned expanded the teaching content,improved the teaching method,strengthened the combination of teaching experiment with scientific research and production practice.On the other hand,this reform consolidated theoretical knowledge of undergraduate students,enhanced their experimental skills,broadened their knowledge horizons,cultivated their scientific thinking,and boosted their innovation ability.

关 键 词：8-羟基喹啉 合成方法 有机化学实验 教学改革 

分 类 号：G642.0[文化科学—高等教育学]