保健食品钙镁咀嚼片的制剂工艺研究  

Preparation on Health Food of Calcium and Magnesium Chewable Tablets

作　　者：何丽君 陈亮 曾荣华 韩亚明 刘春芳 He Lijun;Chen Liang;Zeng Ronghua;Han Yaming;Liu Chunfang(Guangzhou Hanfang Pharmaceutical Co.,Ltd.,National Engineering Research Center of Pharmaceutical Processing Technology of Traditional Chinese Medicine and Drug Innovation,Guangdong Provincial Key Laboratory of Medicinal Lipid,Guangzhou 510240,China)

机构地区：[1]广州白云山汉方现代药业有限公司,中药制药过程技术与新药创制国家工程研究中心,广东省药用脂质重点实验室,广东广州510240

出　　处：《广东化工》2024年第20期54-56,共3页Guangdong Chemical Industry

摘　　要：目的:研究保健食品钙镁咀嚼片的成型工艺。方法:通过筛选填充剂、粘合剂、矫味剂对钙镁咀嚼片的成型工艺进行研究,并通过多指标综合评分法比较制粒效果、片剂指标进行评价。结果:优选可可粉、糖粉等为主要辅料,可提高受试人群的口感接受度。经检测片剂硬度可达到15 kg,检测产品的脆碎度<0.2%,得到的片剂成型性良好。结论:本研究为钙镁咀嚼片的制剂工艺研究确定及实现产业化生产提供参考。Objective:To study the molding technology of health food calcium magnesium chewable tablets.Methods:The molding technology of calcium-magnesium chewable tablets was studied by screening fillers,adhesives and flavoring agents,and the granulation effect and tablet indexes were compared and evaluated by multi-index comprehensive scoring method.Results:Cocoa powder and sugar powder are preferred as main auxiliary materials,which can improve the taste acceptance of the subjects.The hardness of the tablet can reach 15 kg,and the brittleness of the product is less than 0.2%.The obtained tablet has good formability.Conclusion:The preparation method optimized in this study is stable and feasible,which provides scientific experimental basis for the determination of preparation technology and production control of calcium magnesium chewable tablets.

关 键 词：碳酸钙 碳酸镁 片剂 制剂工艺 

分 类 号：TQ[化学工程]