大叶黄精石油醚部位化学成分的分离与鉴定  

Isolation and Identification Chemical Components of the Petroleum Ether Extracted Part from the Rhizoma of Polygonatum Kingianum var.Grandifolium

作　　者：马庆东 董玉婷 易思荣 张宏静 陈春宇 王文祥 易东阳[1,2,3] Ma Qingdong;Dong Yuting;Yi Sirong;Zhang Hongjing;Chen Chunyu;Wang Wenxiang;Yi Dongyang(Chongqing Three Gorges Medical College,Chongqing 404120,China;Chongqing Key Laboratory of Development and Utilization of Daodi Medicinal Materials in Three Gorges Reservoir Area,Chongqing 404120,China;Chongqing Wanzhou Center of Technology Innovation for Traditional Chinese Medicine Preparation Research and Transformation,Chongqing 404120,China;Chongqing University of Arts and Sciences,Chongqing 402160,China)

机构地区：[1]重庆三峡医药高等专科学校,重庆404120 [2]三峡库区道地药材开发利用重庆市重点实验室,重庆404120 [3]重庆市万州区传统中药制剂研发与转化技术创新中心,重庆404120 [4]重庆文理学院,重庆402160

出　　处：《广东化工》2024年第20期177-180,187,共5页Guangdong Chemical Industry

基　　金：重庆市万州区科技计划项目(wzstc-2021041);三峡库区道地药材开发利用重庆市重点实验室(Sys20210001);重庆市教育委员会科学技术研究计划项目(KJZD-K202202703,KJQN202302712);重庆英才计划“包干制”项目(cstc2022ycjh-bgzxm0226);三峡库区道地药材保护与利用多学科交叉创新团队(CXTD202303)。

摘　　要：目的:对百合科植物大叶黄精(Polygonatum kingianum var.grandifolium)干燥根茎石油醚萃取部位的化学成分进行分离与鉴定。方法:大叶黄精药材经提取、萃取得石油醚部位,用硅胶、ODS柱色谱法及半制备高效液相色谱法等分离化合物,运用NMR技术等鉴定化合物结构。结果:共分离得到6个化合物,分别鉴定为甲基麦冬二氢黄酮B(1)、白及内酯(2)、十五烷酸(3)、豆蔻酸(4)、天竺葵酸(5)和十三烷酸乙酯(6)。结论:化合物1~6首次从大叶黄精中分离得到。Objective:To isolate and identify chemical components of the petroleum ether extracted part from the rhizoma of Polygonum kingianum var.grandiflorum,a plant of the Liliaceae.Method:The dried rhizoma of Polygonum kingianum var.grandiflorum were extracted and partitioned to yield the petroleum ether extracted fraction,and it was subjected to silica gel and octadecylsilyl column chromatography,and then separated by high performance liquid chromatography to yield compounds,which were identified by spectral analysis of nuclear magnetic resonance spectra.Result:Six compounds were obtained and identified as Methylophiopogonanone B(1),Striatoliode(2),Pentadecanoic acid(3),Myristic acid(4),Nonanoic acid(5)and Ethyl tridecanoate(6).Conclusion:Compounds 1~6 were for the first time from the titled plant.

关 键 词：大叶黄精 化学成分 甲基麦冬二氢黄酮B 白及内酯 

分 类 号：R284.2[医药卫生—中药学] R931.6[医药卫生—中医学] R932