前沿科研成果融入有机化学实验教学——机械化学条件下格氏试剂的制备与应用  

Integrating Frontline Research Achievements into Organic Chemistry Laboratory Instruction:Preparation and Applications of Grignard Reagents under Mechanochemical Conditions

作　　者：高盼 孙晓环 张国栋 袁宇 陈锋 Gao Pan;Sun Xiaohua;Zhang Guodong;Yuan Yu;Chen Feng(Yangzhou University,Yangzhou 225009,China)

机构地区：[1]扬州大学,江苏扬州225009

出　　处：《广东化工》2024年第20期233-235,共3页Guangdong Chemical Industry

摘　　要：格氏试剂作为有机合成中最为广泛应用的碳亲核试剂,其高效且环保的合成方法一直是化学领域研究的重点。传统的实验室制备方法通常涉及复杂的操作步骤和较高的安全风险。为此,本研究设计引入了球磨技术,作为一种绿色化学合成手段。具体方法是将卤代烃和金属镁在空气条件下直接放入球磨罐中,在无溶剂条件下利用球磨过程中持续施加的机械力来驱动反应,实现固态格氏试剂的高效制备。与传统方法相比,该技术不仅简化了操作步骤,还显著提升了合成效率,减少了有害溶剂的使用。本实验旨在帮助学生深入理解格氏反应的机理,掌握前沿的机械化学合成技术,从而加深对相关学科的认识,提升科研素养,并激发其科研创新能力。Grignard reagents are among the most widely used carbon nucleophiles in organic synthesis,and the development of efficient and environmentally friendly synthesis methods has been a key focus in chemistry.Traditional laboratory preparation methods often involve complex procedures and significant safety risks.To address these issues,this study introduces ball milling technology as a green alternative synthesis approach.Specifically,the method involves directly placing alkyl halides and magnesium metal into a ball mill under air conditions,using the continuous mechanical force applied during the milling process to drive the reaction and efficiently prepare solid-state Grignard reagents under solvent-free conditions.Compared to conventional methods,this technique not only simplifies procedural steps but also significantly enhances synthesis efficiency and reduces the use of hazardous solvents.This experiment is designed to provide students with a deeper understanding of the Grignard reaction mechanism and familiarize them with cutting-edge mechanochemical synthesis techniques,thereby increasing their knowledge of relevant disciplines,improving their research skills,and fostering their innovative capabilities in scientific research.

关 键 词：格氏试剂 机械化学合成 无溶剂 绿色化学 

分 类 号：TQ[化学工程]