毒性测试替代方法及其在化妆品安全风险评估中应用进展  

Alternative toxicity testing and progress in applications of cosmetics safety risk assessment

作　　者：徐飞飞 赵晓晗 周濛 万思雨 肖筱璇 宋佳 杨杏芬 XU Feifei;ZHAO Xiaohan;ZHOU Meng;WAN Siyu;XIAO Xiaoxuan;SONG Jia;YANG Xingfen(School of Public Health,Southern Medical University,Food Safety and Health Research Center,Key Laboratory of Cosmetics Safety Evaluation of China Food and Drug Administration,Guangzhou 510515,China)

机构地区：[1]南方医科大学公共卫生学院,食物安全与健康研究中心,国家药品监督管理局化妆品安全评价重点实验室,广东广州510515

出　　处：《中国药理学与毒理学杂志》2024年第10期723-733,共11页Chinese Journal of Pharmacology and Toxicology

基　　金：国家重点研发计划(2022YFF0711101);国家自然科学基金(82373600);国家自然科学基金(82073599);广东省特支计划(2021TX06N107);广东省药品监督管理局2022年科技创新重点实验室项目(2022ZDZ09)。

摘　　要：随着工业和经济的快速发展,大量化学物质涌现,风险管理难度加大。传统的风险评估主要依赖于动物试验开展毒性测试,然而动物试验周期长,成本高,已无法满足风险评估的现实需求。毒性测试替代技术的日益成熟,标志着快速、灵敏、准确识别化学物质毒性成为可能。本文围绕毒性测试替代方法的研究与应用,综述毒性替代测试方法的背景、发展和国内外研究现状,及其在化妆品安全风险评估领域的应用进展,并对当前我国替代测试技术和风险评估发展过程中存在的问题进行了探讨,为我国化妆品健康风险评估体系建设提供参考。With the rapid development of industry and economy,the emergence of a large number of chemicals has made of risk management more difficult.Traditional risk assessment relies on animal experiments for toxicity testing.However,animal experiments are time-consuming,costly,and unable to meet the practical needs of risk assessment.The increasing maturity of toxicity testing alternative technologies signifies the possibility of rapid,sensitive,and accurate identification of chemical toxicity.This article focuses on the research and applications of alternative toxicity testing by reviewing the background,developments,and current research at home and abroad.It also discusses the progress in alternative testing methods in such areas as cosmetics and food safety risk assessment and explores the problems with the development of alternative testing technologies and risk assessment in China.This review aims to provide a reference for the system construction of cosmetics health risk assessment in China.

关 键 词：毒性测试替代方法 健康风险评估 化妆品 新途径方法 

分 类 号：R99[医药卫生—毒理学]