整合测试与评估方法(IATA)及其应用进展  

Progress in integrated approach to testing and assessment(IATA)and its applications

作　　者：彭辉 宗尤佳 彭双清 郭家彬 PENG Hui;ZONG Youjia;PENG Shuangqing;GUO Jiabin(Center of Disease Control and Prevention,PLA,Beijing 100071,China;School of Public Health,China Medical University,Shenyang 110122,China)

机构地区：[1]中国人民解放军疾病预防控制中心,北京100071 [2]中国医科大学公共卫生学院,辽宁沈阳110122

出　　处：《中国药理学与毒理学杂志》2024年第10期742-751,共10页Chinese Journal of Pharmacology and Toxicology

基　　金：国家重点研发计划(2022YFF0711101)。

摘　　要：整合测试与评估方法(IATA)是一种毒理学评估决策的新技术方法,它将化学物质现有的理化特性、动物测试和非动物测试等多种来源的信息源进行整合,通过一系列迭代策略的评估和分析,以获得风险评估结论,可为制定化学物质的风险管理决策提供依据。IATA已在皮肤致敏、眼刺激和遗传毒性等领域得到越来越广泛的应用。本综述简要介绍IATA相关的概念内涵,梳理框架要素和序贯流程,阐释常用的框架构建方法,分享多种暴露场景下的应用案例,并对IATA未来研究方向进行展望,以期为化学物质风险评估提供更好的方法学支撑。Integrated Approaches to Testing and Assessment(IATA)is a toxicological assessment decision-making method that integrates existing information from various sources,including physical and chemical properties,animal testing,and non-animal testing.Through the evaluation and analysis of a series of iterative strategies,it ultimately obtains risk assessment conclusions,thereby providing a basis for risk management decisions regarding chemical substances.The use of IATA is becoming increasingly prevalent in such areas as ocular irritation and genotoxicity.This paper introduces the conceptual connotation of IATA,sorts out the framework elements and sequential processes,explains the commonly used framework construction methods,shares cases of application in various exposure scenarios,and finally envisions future research directions in order to provide better methodological support for the risk assessment of chemical substances.

关 键 词：整合测试与评估方法 有害结局路径 确定性方法 新途径方法 下一代风险评估 

分 类 号：R99[医药卫生—毒理学]